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UniPep - a database for human N-linked glycosites: a resource for biomarker discovery

Hui Zhang1*, Paul Loriaux1, Jimmy Eng1, David Campbell1, Andrew Keller1, Pat Moss1, Richard Bonneau2, Ning Zhang1, Yong Zhou1, Bernd Wollscheid3, Kelly Cooke1, Eugene C Yi1, Hookeun Lee3, Elaine R Peskind4, Jing Zhang5, Richard D Smith6 and Ruedi Aebersold3

Author Affiliations

1 Institute for Systems Biology, Seattle, WA 98103, USA

2 NYU Center for Comparative Functional Genomics, New York, NY, USA

3 Institute for Molecular Systems Biology, ETH Zurich and Faculty of Sciences, University of Zurich, Switzerland

4 VA Puget Sound Health Care System, Seattle, WA 98108, USA

5 Harborview Medical Center, University of Washington School of Medicine, Seattle, WA 98104, USA

6 Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99352, USA

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Genome Biology 2006, 7:R73  doi:10.1186/gb-2006-7-8-r73

Published: 10 August 2006

Abstract

There has been considerable recent interest in proteomic analyses of plasma for the purpose of discovering biomarkers. Profiling N-linked glycopeptides is a particularly promising method because the population of N-linked glycosites represents the proteomes of plasma, the cell surface, and secreted proteins at very low redundancy and provides a compelling link between the tissue and plasma proteomes. Here, we describe UniPep http://www.unipep.org webcite - a database of human N-linked glycosites - as a resource for biomarker discovery.