UniPep - a database for human N-linked glycosites: a resource for biomarker discovery

doi:10.1186/gb-2006-7-8-r73

Genome Biology

Volume 7
Issue 8

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Zhang H
Loriaux P
Eng J
Campbell D
Keller A
Moss P
Bonneau R
Zhang N
Zhou Y
Wollscheid B
Cooke K
Yi EC
Lee H
Peskind ER
Zhang J
Smith RD
Aebersold R

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Zhang H
Loriaux P
Eng J
Campbell D
Keller A
Moss P
Bonneau R
Zhang N
Zhou Y
Wollscheid B
Cooke K
Yi EC
Lee H
Peskind ER
Zhang J
Smith RD
Aebersold R
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UniPep - a database for human N-linked glycosites: a resource for biomarker discovery

Hui Zhang¹ , Paul Loriaux¹ , Jimmy Eng¹ , David Campbell¹ , Andrew Keller¹ , Pat Moss¹ , Richard Bonneau² , Ning Zhang¹ , Yong Zhou¹ , Bernd Wollscheid³ , Kelly Cooke¹ , Eugene C Yi¹ , Hookeun Lee³ , Elaine R Peskind⁴ , Jing Zhang⁵ , Richard D Smith⁶ and Ruedi Aebersold³

¹Institute for Systems Biology, Seattle, WA 98103, USA

²NYU Center for Comparative Functional Genomics, New York, NY, USA

³Institute for Molecular Systems Biology, ETH Zurich and Faculty of Sciences, University of Zurich, Switzerland

⁴VA Puget Sound Health Care System, Seattle, WA 98108, USA

⁵Harborview Medical Center, University of Washington School of Medicine, Seattle, WA 98104, USA

⁶Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99352, USA

author email corresponding author email

Genome Biology 2006, 7:R73doi:10.1186/gb-2006-7-8-r73


Published:	10 August 2006

Subject areas: Biochemistry and structural biology, Bioinformatics

Abstract

There has been considerable recent interest in proteomic analyses of plasma for the purpose of discovering biomarkers. Profiling N-linked glycopeptides is a particularly promising method because the population of N-linked glycosites represents the proteomes of plasma, the cell surface, and secreted proteins at very low redundancy and provides a compelling link between the tissue and plasma proteomes. Here, we describe UniPep http://www.unipep.org webcite - a database of human N-linked glycosites - as a resource for biomarker discovery.