Genome Biology

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Functional genomics of the yeast DNA-damage response

Gerard Cagney1, David Alvaro2, Robert JD Reid2, Peter H Thorpe2, Rodney Rothstein2 and Nevan J Krogan3,4*

Author Affiliations

1 Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland

2 Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA

3 Department of Cellular and Molecular Pharmacology, University of California-San Francisco, 1700 4th Street, San Francisco, CA 94143, USA

4 California Institute for Quantitative Biomedical Research, University of California-San Francisco, 1700 4th Street, San Francisco, CA 94143, USA

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Genome Biology 2006, 7:233 doi:10.1186/gb-2006-7-9-233

Published: 7 September 2006

Abstract

High-throughput approaches are beginning to have an impact on many areas of yeast biology. Two recent studies, using different experimental platforms, provide insight into new pathways involved in the response of yeast to DNA damage.