Genome Biology

official impact factor 6.89

Open Access Highly Access Software

PhyloFacts: an online structural phylogenomic encyclopedia for protein functional and structural classification

Nandini Krishnamurthy, Duncan P Brown, Dan Kirshner and Kimmen Sjölander*

Author Affiliations

Department of Bioengineering, 473 Evans Hall #1762, University of California, Berkeley, CA 94720, USA

For all author emails, please log on.

Genome Biology 2006, 7:R83 doi:10.1186/gb-2006-7-9-r83

Published: 14 September 2006

Abstract

The Berkeley Phylogenomics Group presents PhyloFacts, a structural phylogenomic encyclopedia containing almost 10,000 'books' for protein families and domains, with pre-calculated structural, functional and evolutionary analyses. PhyloFacts enables biologists to avoid the systematic errors associated with function prediction by homology through the integration of a variety of experimental data and bioinformatics methods in an evolutionary framework. Users can submit sequences for classification to families and functional subfamilies. PhyloFacts is available as a worldwide web resource from http://phylogenomics.berkeley.edu/phylofacts webcite.