Genome Biology

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Open Access Research

Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes

Katleen De Preter1, Jo Vandesompele1, Pierre Heimann2, Nurten Yigit1, Siv Beckman3, Alexander Schramm4, Angelika Eggert4, Raymond L Stallings5, Yves Benoit6, Marleen Renard7, Anne D Paepe1, Geneviève Laureys6, Sven Påhlman3 and Frank Speleman1*

Author Affiliations

1 Center for Medical Genetics, Ghent University Hospital, De Pintelaan, B-9000 Ghent, Belgium

2 Department of Medical Genetics, University Hospital Erasme, Lenniksebaan, B-1070 Brussels, Belgium

3 Division of Molecular Medicine, Department of Laboratory Medicine, Lund University, University Hospital MAS, SE-20502 Malmö, Sweden

4 Department of Pediatric Oncology and Hematology, University Hospital of Essen, Hufelandstr, Essen 45122, Germany

5 Children's Cancer Research Institute, University of Texas Health Science Center, Floyd Curl Drive, Mail Code 7784, San Antonio, Texas 78229-3900, USA

6 Department of Pediatrics, Ghent University Hospital, De Pintelaan, B-9000 Ghent, Belgium

7 Department of Pediatrics, UZ Gasthuisberg, Herestraat, B-3000 Leuven, Belgium

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Genome Biology 2006, 7:R84 doi:10.1186/gb-2006-7-9-r84

Published: 21 September 2006

Additional files

Additional data file 1:

RNA quality and quantity measures, validation of Affymetrix chip results, and Affymetrix chip quality parameters

Format: DOC Size: 1.4MB Download file

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Additional data file 2:

Genes that are differentially expressed in neuroblast versus cortex samples, in neuroblast versus favorable (F) and/or unfavorable (UF) neuroblastoma, and in favorable versus unfavorable neuroblastoma

Format: XLS Size: 349KB Download file

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Additional data file 3:

Results of NBGS analysis of the genes that are differentially expressed between neuroblasts and (favorable and/or unfavorable) neuroblastomas (gene lists in Additional data file 1)

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Open Data

Additional data file 4:

Genes of GO class neurogenesis and proneural genes that are expressed in neuroblast samples (> 36th percentile)

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Open Data