Figure 3.

Two pseudogenes inconsistent with GENCODE gene annotation. (a) A pseudogene in ENr122: 359245-366200 (+) and its alignment with an ENSEMBL protein ENSP00000331368 (Serpin B8). This pseudogene overlaps a GENCODE gene whose transcript (ID: 'AC009802.2-001') contained the three pseudo-exons and one additional 5' exon. (b) A pseudogene at ENm005:200473-211501 (-) and its alignment with an ENSEMBL protein ENSP00000283507 (TCP-10 homolog). The first four pseudo-exons were included in a five-exon GENCODE transcript (ID: 'AP000274.7-001'). The frameshift mutations ('!' in the alignment) in both pseudogenes are highlighted.