Table 5

Accuracy of human gene prediction using similar mouse proteins

Sn ex
 Sno ex
 Sp ex
 Sn nuc
 Sp nuc
 CC
 %CG
Similarity of mouse protein >90% in 921 sequences
     Fgenesh
 86.2
 91.7
 88.6
 93.9
 93.4
 0.9334
 34
     Genwise
 93.9
 97.6
 95.9
 99.0
 99.6
 0.9926
 66
     Fgenesh+
 97.3
 98.9
 98.0
 99.1
 99.6
 0.9936
 81
     Prot_map
 95.9
 98.3
 96.9
 99.1
 99.5
 0.9924
 73
80% < similarity of mouse protein <90% in 1,441 sequences
     Fgenesh
 85.8
 92.1
 87.7
 94.0
 93.4
 0.9334
 30
     Genewise
 92.6
 98.0
 94.1
 98.9
 99.5
 0.9912
 58
     Fgenesh+
 96.8
 99.0
 97.2
 99.1
 99.5
 0.9929
 77
     Prot_map
 93.9
 98.5
 94.1
 98.9
 99.3
 0.9898
 60

Sn_ex, sensitivity on the exon level (exact exon predictions); Sno_ex, sensitivity with exon overlap; Sp_ex, specificity on the exon level; Sn_nuc, sensitivity, nucleotides; Sp_nuc, specificity, nucleotides; CC, correlation coefficient; %CG, percent of genes predicted completely correctly (no missing and no extra exons, and all exon boundaries are predicted exactly correctly).

Solovyev et al. Genome Biology 2006 7(Suppl 1):S10   doi:10.1186/gb-2006-7-s1-s10