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Analysis of genetic systems using experimental evolution and whole-genome sequencing

Matthew Hegreness12 and Roy Kishony13*

Author Affiliations

1 Department of Systems Biology, Harvard Medical School, Longwood Avenue, Boston, MA 02115, USA

2 Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA

3 School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA

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Genome Biology 2007, 8:201  doi:10.1186/gb-2007-8-1-201

Published: 1 February 2007

Abstract

The application of whole-genome sequencing to the study of microbial evolution promises to reveal the complex functional networks of mutations that underlie adaptation. A recent study of parallel evolution in populations of Escherichia coli shows how adaptation involves both functional changes to specific proteins as well as global changes in regulation.