Analysis of genetic systems using experimental evolution and whole-genome sequencing
1 Department of Systems Biology, Harvard Medical School, Longwood Avenue, Boston, MA 02115, USA
2 Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
3 School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
Genome Biology 2007, 8:201 doi:10.1186/gb-2007-8-1-201Published: 1 February 2007
The application of whole-genome sequencing to the study of microbial evolution promises to reveal the complex functional networks of mutations that underlie adaptation. A recent study of parallel evolution in populations of Escherichia coli shows how adaptation involves both functional changes to specific proteins as well as global changes in regulation.