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Signaling netwErks get the global treatment

Michael B Yaffe123* and Forest M White13

Author Affiliations

1 Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

2 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

3 Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

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Genome Biology 2007, 8:202  doi:10.1186/gb-2007-8-1-202

Published: 1 February 2007

Abstract

Two landmark studies of cell signaling, by RNA interference and phosphoproteomics, provide complementary global views of the pathways downstream of receptor kinases, including those regulated by Erks.