Figure 2.

Patterns of gene expression changes induced by positive and negative selection in the B10^k and NOD^k strains. Analysis of Affymetrix GeneChip data segregated those probesets that were significantly changed upon positive and/or negative selection (p < 0.005) into patterns A to F based on logical sets of significant contrasts (p < 0.05), where patterns are defined by the relative expression during pre-selection (PreS, left), positive selection (S+, middle) and negative selection (S-, right). The number of probesets falling into each pattern in B10^k and NOD^k mice is listed on the expression pattern. Assignment of probesets to patterns was based only on direction of change, thus the graphical depictions do not represent the degree of change.