Table 6

High quality candidates for the defective thymic deletion allele linked to D1mit181

Gene

Probeset

Group

Distance (cM)

Fold change

Function

Dnajb10

1448657_a_at

3

0.5

1.7

Homology to heat shock protein DnaJ (Hsp40)

Dnpep

1437437_x_at

1

0.5

1.6

Putative aspartyl aminopeptidase function

Farslb

1423708_a_at

3

2.5

2.0

Phenylalanine-tRNA synthetase-like, beta subunit

Acadl

1448987_at

3

4.8

1.9

Involved in the initial step of mitochondrial beta-oxidation of straight-chain fatty acids

Pdcd1

1449835_at

1

11.8

1.9

Negative regulator of T cell function [77], reduces positive selection [78], blockade induces diabetes in NOD mice [81], KO has autoimmune symptoms [79,80]

Rps24

1453362_x_at

3

12.0

3.5

Ribosome constituent

Hspa8

1420622_a_at

1

17.6

2.0

Aid in the targeting of the MHC class II complex to endocytic compartments [98], regulates cell cycle [99]

Prim2

1418035_a_at

3

25.7

3.7

DNA primase [100] involved in primer initiation, elongation, and counting [101]

KO, knockout.

Liston et al. Genome Biology 2007 8:R12   doi:10.1186/gb-2007-8-1-r12