Table 2 |
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|
Expression of GABA and JAK signaling-related genes in brain of COX knockout mice |
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|
Gene name |
Region |
COX-1-/- |
COX-2-/- |
|
|
|||
|
GAT3 |
Cerebral cortex |
-42% (-1.86) |
+66% (+1.68) |
|
GABRB1 |
Cerebral cortex |
- |
-28% (ND) |
|
GABRB1 |
Hippocampus |
- |
-46% (-2.32) |
|
JAK 1 |
Hippocampus |
+96% (+1.56) |
- |
|
JAK 2 |
Hippocampus |
- |
-18% (-2.09) |
|
|
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|
Percentage change in expression, as validated by Q-PCR, is provided, along with microarray-determined z ratios (in parenthesis) for each genotype comparison. Janus kinase (JAK)1 and 2 expression are altered only in hippocampus of COX-1-/- and COX-2-/- mice. COX, cyclooxygenase; GABA, γ-aminobutyric acid; GABRB1, GABA-A receptor subunit β1; GAT, GABA transporter; ND, not differentially expressed in microarray analysis. |
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|
Toscano et al. Genome Biology 2007 8:R14 doi:10.1186/gb-2007-8-1-r14 |
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