Figure 3.

Significant TF pair interactions. Eighty-four TF pairs were identified to have significant synergistic effects on expression of target genes. Nodes represent TFs and edges indicate that two connected TFs form a module to regulate a set of genes. The TF pair is determined to be significant if they share at least four functional target genes and if the posterior interval for the interaction effect term g_jk is significantly different from zero (details given in Additional data file 1 [Supplementary methods]). The target genes of each regulator are not shown. Regulators without significant interaction with other TFs are not shown. This network is illustrated with Cytoscape [33]. TF, transcription factor.