Genome Biology

official impact factor 6.89

Open Access Research

Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection

Monica C Panelli1, Mitchell E Stashower2, Herbert B Slade3, Kina Smith1, Christopher Norwood4, Andrea Abati5, Patricia Fetsch5, Armando Filie5, Shelley-Ann Walters3, Calvin Astry3, Eleonora Aricó1, Yingdong Zhao6, Silvia Selleri1,7, Ena Wang1 and Francesco M Marincola1*

Author Affiliations

1 Immunogenetics Section, Department of Transfusion Medicine, Clinical Center National Institutes of Health, Bethesda, MD 20892, USA

2 The Clinical Skin Center of Northern Virginia, Fairfax, VA 22033, USA

3 3M Pharmaceuticals, St Paul, MN 55144-1000, USA

4 Department of Dermatology, National Naval Medical Center, Bethesda, MD 20889, USA

5 Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA

6 Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA

7 Universita' degli Studi di Milano, Department of Human Morphology, via Mangiagalli, 20133 Milan, Italy

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Genome Biology 2007, 8:R8 doi:10.1186/gb-2007-8-1-r8

Published: 15 January 2007

Additional files

Additional data file 1:

List of genes previously shown to be associated with the stimulation of various cell types with IFN-α.

Format: TXT Size: 48KB Download file

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Additional data file 2:

Extended version of the Materials and methods, providing full disclosure of the methodology used.

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Additional data file 3:

Complete list of the 637 genes specifically induced by imiquimod treatment based on the statistical approach presented in the text.

Format: TXT Size: 584KB Download file

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Additional data file 4:

The mining strategy that was implemented for the preparation of Figure 1c,d.

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