Opinion
Making the most of high-throughput protein-interaction data
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* Corresponding author: Robert Gentleman rgentlem@fhcrc.org
1 Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
2 European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge CB10 1SD, UK
Genome Biology 2007, 8:112 doi:10.1186/gb-2007-8-10-112
Published: 2 November 2007Abstract
We review the estimation of coverage and error rate in high-throughput protein-protein interaction datasets and argue that reports of the low quality of such data are to a substantial extent based on misinterpretations. Probabilistic statistical models and methods can be used to estimate properties of interest and to make the best use of the available data.