Making the most of high-throughput protein-interaction data

doi:10.1186/gb-2007-8-10-112

Genome Biology

Volume 8
Issue 10

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Opinion

Making the most of high-throughput protein-interaction data

Robert Gentleman¹ and Wolfgang Huber²

¹Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA

²European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge CB10 1SD, UK

author email corresponding author email

Genome Biology 2007, 8:112doi:10.1186/gb-2007-8-10-112


Published:	2 November 2007

Subject areas: Bioinformatics, Genome studies, Biochemistry and structural biology

Abstract

We review the estimation of coverage and error rate in high-throughput protein-protein interaction datasets and argue that reports of the low quality of such data are to a substantial extent based on misinterpretations. Probabilistic statistical models and methods can be used to estimate properties of interest and to make the best use of the available data.