Genome Biology

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Open Access Research

A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans

Ana C Gomes1, Isabel Miranda1, Raquel M Silva1, Gabriela R Moura1, Benjamin Thomas2, Alexandre Akoulitchev2 and Manuel AS Santos1*

Author Affiliations

1 CESAM & Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal

2 Central Proteomics Facility, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK

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Genome Biology 2007, 8:R206 doi:10.1186/gb-2007-8-10-r206

Published: 4 October 2007

Additional files

Additional data file 1:

Presented is a figure showing maps of the pUA63 and pUA65 plasmids that were used to quantify CUG decoding ambiguity in C. albicans

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Additional data file 2:

Presented is a figure of CUG codon context in various yeast species, including C. albicans.

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Additional data file 3:

Presented is a figure of the maps of pUA12 and pUA15 plasmids that were used throughout the study.

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Additional data file 4:

Presented is a figure showing that elimination of the pUA15 vector in 5-FOA selective media results in disappearance of phenotypic diversity.

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Additional data file 5:

Presented is a figure showing that the pUA15 plasmid did not alter the tRNACAGSer locus.

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Additional data file 6:

Presented is a figure of the amplification of the MTL locus of CAI-4/pUA12 and CAI-4/pUA15 cells.

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