Figure 4.

Association of miRNA expression and DNA copy number. miRNAs mapping to regions of genomic aberration were plotted according to chromosome and genomic location. Heatmap colors represent relative miRNA expression as shown in the color key. Expression values for samples with genomic loss (L), unaltered samples (N), samples with genomic gain (G) and amplification (A) were summarized by their mean, respectively, with numbers of samples as indicated. miRNAs transcribed from multiple loci are indicated in blue. Adjacent miRNAs not separated by a black line are less than 50 kb apart. Significance levels correspond to unadjusted p values obtained by a non-parametric Wilcoxon rank sum test (* p < 0.05, ** p < 0.01, *** p < 0.001). Given the high dependence of the performed tests, p values were not adjusted for multiple testing.