Figure 6.

Genes required for miRNA biogenesis are differentially expressed according to molecular subtype and ER status. Shown are boxplots of Illumina log2 intensities for (a) AGO2 (EIF2C2), (b) DICER1, (c) DROSHA (RNASEN). Data are based on 58 samples that could be classified according to molecular subtype (17 basal-like (red), 5 HER2+ (pink), 18 luminal A (dark blue), 8 luminal B (light blue), 10 normal-like (green)) and 99 samples with known ER status (31 ER- (blue), 68 ER+ (yellow)). (d) Boxplots of mean miRNA expression after control-based normalization. Data are based on 51 samples that could be classified according to molecular subtype (16 basal-like (red), 5 HER2+ (pink), 15 luminal A (dark blue), 9 luminal B (light blue), 6 normal-like (green)) and 93 samples with known ER status (33 ER- (blue), 60 ER+ (yellow)). Black bars indicate the median; boxes interquartile range; whiskers most extreme data points not exceeding 1.5 times the interquartile range; points outliers. P values are based on non-parametric Kruskal-Wallis tests for subtype and Wilcoxon rank sum tests for ER status.

Blenkiron et al. Genome Biology 2007 8:R214   doi:10.1186/gb-2007-8-10-r214
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