Table 4

Univariate and multivariate survival analysis

Factor

OS HR (95% CI) p value

TTDM HR (95% CI) p value

ER

1.7 (0.9-2.5) 0.10

1.7 (0.8-3.3) 0.13

p53mut

1.7 (0.9-3.0) 0.09

2.1 (1.1-4.2) 0.03

LN

2.4 (1.4-4.0) 8 × 10^-4

4.3 (2.3-8.3) < 10^-4

Size

1.3 (1.0-1.7) 0.03

1.3 (0.9-1.7) 0.16

Grade

2.0 (1.2-3.4) 0.009

1.8 (0.9-3.3) 0.08

NPI

2.5 (1.4-4.3) 0.001

2.8 (1.4-5.8) 0.003

5-amp

2.6 (1.5-4.6) 3 × 10^-4

3.0 (1.6-5.8) 5 × 10^-4

5-amp*+NPI

2.3 (1.3-4) 0.003

2.6 (1.4-5.1) 0.004

5-amp+NPI*

2.2 (1.2-3.9) 0.008

2.5 (1.2-5.1) 0.02

Univariate and multivariate Cox proportional hazards analysis with overall survival (OS) and time to distant metastasis (TTDM) as endpoints. Univariate analysis was performed for ER status (1, negative; 0, positive), p53 mutation (1, mutant; 0, wild-type), lymph node status (1, positive; 0, negative), size (1, ≥2.5 cm; 0, <2.5 cm), grade (1, high or intermediate; 0, low), NPI (1, ≥3.8; 0, <3.8) and 5-amp (1, amplification in any of the five regions; 0, no amplification in any region). * indicates the corresponding hazard ratio estimate in the multivariate model that included 5-amp and NPI.

Chin et al. Genome Biology 2007 8:R215   doi:10.1186/gb-2007-8-10-r215