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Table 4
CRP gene haploinsufficiency
CRP gene^a		Genetic analysis^b

Symbol	Location	CRP gene mutations^{c, d}	Deletions removing a single CRP gene^{c, e}	Other evidence	Is the CRP gene a Minute?^f	No. of candidate Minute genes^g	Minute synonym^h	Referenceⁱ

X chromosome
RpL36	1B12		M		Yes		M(1)1B	[53]
RpL22	1C4	+	+		No
sta/RpSA	2B1	+	+		No
RpL35	5A11			Lies in a gap in deletion coverage. 5A6-13 aneuploids were Minute (Merriam et al. [55])	Likely	33	M(1)5A
RpL7A	6B1		M		Likely	2	M(1)5D6A
RpL17	6C10			Lies in a gap in deletion coverage	Likely	12	New?
RpS6	7C2	M	M		Yes		M(1)7BC and M(1)7C	[2]
RpS14a	7C6-7			A deletion that removes RpS14a and RpS14b is not Minute [95]	No
*RpS14b*	7C8			A deletion that removes RpS14a and RpS14b is not Minute [95]	No
RpS28b	8E7			Lies in a gap in deletion coverage. A Minute mutation was mapped to 8D8-9A2 [153]	Likely	17	M(1)8F
RpS15Aa	11E11-12		M		Likely	8	M(1)11F
RpL37a	13B1			Lies in a gap in deletion coverage. 12F6-13B6 aneuploids were Minute (Merriam et al. [55])	Likely	2	M(1)13A
RpS19a	14F4		M		Likely	14	M(1)14E
RpS5a	15E5-7	M		Lies in a gap in deletion coverage	Yes		M(1)15D	[44]
RpS10b	18D3	M	M		Yes		M(1)18C
Chromosome arm 2L
RpLP1	21C2	M	M		Yes		M(2)21C	[50]
oho23B/RpS21	23B6	M	M		Yes		M(2)23B	[49]
RpL40	24E1		M		Likely	4	M(2)24D
RpL27A	24F3	M	M		Yes		M(2)24F
RpL37A	25C4		M	The interval between flanking non-Minute deletions contains only RpL37A	Yes		M(2)25C
RpL36A	28D3		M		Likely	5	M(2)28DE*
RpS13	29B2	M	M		Yes		M(2)29B*	[45]
sop/RpS2	30E1	+	+		No
RpL13	30F3		M	The interval between flanking non-Minute deletions contains only RpL13	Yes		M(2)31A
RpL7	31B1		M		Likely	2	M(2)31A
RpS27A	31E1		M		Likely	6	M(2)31E*
RpL9	32C1	M	M		Yes		M(2)32D	[46]
RpL24	34B10		M		Likely	8	M(2)34BC*
RpS26	36F4	M	M		Yes		M(2)36F
RpL30	37B9	+	+		No
RpL21	40A-B		M		Likely	10	M(2)39F
RpL5	40B	M	M		Yes		M(2)40B*	[51]
Chromosome arm 2R
RpL38	41C-E	M	M		Yes		M(2)41A	[51]
RpL31	45F5	M		Lies in a gap in deletion coverage	Yes		M(2)45F*
*RpS15Ab*	47C1		+		No
RpS11	48E8-9	M		Lies in a gap in deletion coverage	Yes		M(2)48E*
RpS23	50E4		M		Likely	2	M(2)50E*
RpS15	53C8			M(2)53¹Minute phenotype rescued by duplication of 51F-54A [154] but not by a RpLP2 transgene [155]	Likely	16	M(2)53
RpLP2	53C9		M		Likely	5	M(2)53
RpL18A	54C3			Lies in a gap in deletion coverage	Likely	16	New?
RpL11	56D7			Lies in a gap in deletion coverage. 56C-D aneuploids were Minute [55]	Likely	3	M(2)56CD
RpS18	56F11		M		Likely	2	M(2)56F
RpL29	57D8		+		No
RpS16	58F1			Deletions that remove both RpS16 and RpS24 are Minute. The Minute mutations M(2)58F¹and RpS24^SH2053complement, suggesting RpS16 is a Minute gene	Likely	25	M(2)58F
RpS24	58F3	M		Deletions that remove both RpS16 and RpS24 are Minute	Yes		M(2)58F
RpL23	59B3		+		No
*RpL37b*	59C4		+		No
RpL12	60B7			RpL12 and RpL39 lie in the same gap in deletion coverage. 60B3-10 aneuploids were Minute [156]	Likely	9	M(2)60B
RpL39	60B7			RpL12 and RpL39 lie in the same gap in deletion coverage. 60B3-10 aneuploids were Minute [156]	Likely	9	M(2)60B
RpL41	60E5	+	+		No
RpL19	60E11	M		A deletion that removes RpL19 and RpL41 is Minute	Yes		M(2)60E	[42]
Chromosome arm 3L
RpL23A	62A10		M		Likely	8	M(3)62A
RpL8	62E7			Lies in a gap in deletion coverage containing only RpL8. 62E-63A aneuploids were Minute [54]	Yes		M(3)62F
RpL28	63B14		M		Likely	10	M(3)63B
RpL18	65E9		M		Likely	8	M(3)65F
RpL14	66D8	M		Lies in a gap in deletion coverage	Yes		M(3)66D	[47]
RpS17	67B5			A deletion removing both RpS17 and RpS9 is Minute. The unsequenced Minute mutations RpS17⁴and RpS17⁶complement the Minute mutation RpS9^EP3299, suggesting RpS17 is a Minute gene	Likely	13	M(3)67C
RpS9	67B11	M		A deletion removing both RpS17 and RpS9 is Minute	Yes		M(3)67C
RpL10Ab	68E1		+		No
RpS12	69F5		+	A deletion that removes RpS12 and RpS4 is Minute	No
RpS4	69F6			A deletion that removes RpS12 and RpS4 is Minute	Likely	2	M(3)69E
RpL26	75E4		+		No
RpLP0	79B2	+	+		No
Qm/RpL10	80A		M		Likely	23	M(3)80
RpL15	80F		M		Likely	= 11	M(3)80F*
Chromosome arm 3R
RpL35A	83A4			Lies in a gap in deletion coverage	Likely	3	New?
RpL13A	83B6-7	M		Lies in a gap in deletion coverage	Yes		M(3)83B*	[52]
RpL34b	85D15			Lies in a gap in deletion coverage	Likely	3	New?
RpS29	85E8	M	M		Yes		M(3)85E
RpS25	86D8			A deletion that removes RpS25 and RpL3 is Minute	Likely	14	M(3)86D
RpL3	86D8	+			No
*RpS5b*	88D6	+	+		No
*RpL10Aa*	88D10		+		No
RpS20	93A1			A deletion that removes RpS20 and RpS30 is Minute	Likely	21	M(3)93A*
RpS30	93A2			A deletion that removes RpS20 and RpS30 is Minute	Likely	21	M(3)93A*
RpS3	94E13	M	M		Yes		M(3)95A	[43]
*RpS19b*	95C13		+		No
RpS27	96C8		M		Likely	5	M(3)96C
RpL27	96E9-10		M		Likely	6	M(3)96CF
*RpL34a*	96F10		+		No
*RpS10a*	98A14		+		No
RpL4	98B6		M		Likely	6	M(3)98B*
RpS8	99C4			Lies in a gap in deletion coverage. 99B aneuploids were Minute [157]	Likely	11	M(3)99B
*RpS28a*	99D2			The Minute phenotype of a deletion removing RpS28a and RpL32 is rescued by a RpL32 transgene [41]	No
RpL32	99D3			The Minute phenotype of a deletion removing RpS28a and RpL32 is rescued by a RpL32 transgene [41]	Yes		M(3)99D	[41]
RpS7	99E2			Lies in a gap in deletion coverage. 99E-F aneuploids were Minute [157]	Likely	11	M(3)99E
RpL6	100C7			Lies in a gap in deletion coverage. 100C-F aneuploids were Minute [157]	Likely	16	M(3)100CF
Chromosome 4
RpS3A	101F1	M	M		Yes		M(4)101	[48]

^aBold font indicates the member of a duplicate gene pair that is expressed in a small number of tissues and/or at relatively low levels. ^bComplete details are given in Additional data file 4. ^c'M' indicates that mutation or deletion heterozygotes display a Minute bristle phenotype; '+' indicates they are wild type; a blank indicates the absence of appropriate mutations or deletions. ^dMutations mapped molecularly to a single CRP gene. ^eDeletions removing several genes, but only a single CRP gene. ^fJudged according to evidence summarized in previous three columns and presented in detail in Additional data file 4. ^gThe maximum number of genes that could correspond to the Minute; defined as the number of genes between the relevant deletion breakpoints minus the number of genes with non-Minute mutations. ^hMinute synonyms from literature sources (see Additional data files 3 and 4). Asterisks indicate new synonyms assigned in this study. ⁱReference demonstrating definite correspondence between a Minute locus and CRP gene. Where no reference is given, the correspondence is shown for the first time in this study.
Marygold et al. Genome Biology 2007 8:R216 doi:10.1186/gb-2007-8-10-r216

Table 4