Genome Biology

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Harnessing naturally randomized transcription to infer regulatory relationships among genes

Lin S Chen, Frank Emmert-Streib and John D Storey*

Genome Biology 2007, 8:R219 doi:10.1186/gb-2007-8-10-r219

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BioMed Central: 2 citations

Methodology article   Open Access Highly Accessed

Disentangling molecular relationships with a causal inference test

Joshua Millstein, Bin Zhang, Jun Zhu, Eric E Schadt BMC Genetics 2009, 10:23 (27 May 2009)

Research article   Open Access Highly Accessed

Can single knockouts accurately single out gene functions?

David Deutscher, Isaac Meilijson, Stefan Schuster, Eytan Ruppin BMC Systems Biology 2008, 2:50 (18 June 2008)

Complex biological systems are often studied by single gene knockouts, however an in silico yeast model finds that single-perturbation analyzes frequently fail to reveal all the genes involved in a system or their full functions.