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Main genes regulated by Hfe deficiency in liver and pertaining to the enriched functional categories fatty acid β-oxidation and cholesterol metabolism |
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| Gene |
Protein |
S-score |
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| D2 KO versus WT |
B6 KO versus WT |
D2 WT versus B6 WT |
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| Fatty acid β-oxidation |
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| Cpt1a |
Carnitine palmitoyl transferase 1a |
-2.95 |
-1.94 |
NS |
| Cpt2 |
Carnitine palmitoyl transferase 2 |
-2.59 |
NS |
NS |
| Acadm |
Acyl-CoA dehydrogenase, medium chain |
-2.97 |
-1.80 |
NS |
| Acadl |
Acyl-CoA dehydrogenase, long chain |
-3.00 |
NS |
NS |
| Acadvl |
Acyl-CaA dehydrogenase, very long chain |
-2.40 |
NS |
NS |
| Ehhadh |
Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase |
-2.30 |
NS |
NS |
| Hadha |
Tripartite protein, alpha subunit |
-2.08 |
-1.58 |
NS |
| Hadhb |
Tripartite protein, beta subunit |
-2.96 |
-1.90 |
NS |
| Hadh2 |
Hydroxyacyl-CoA dehydrogenase type II |
NS |
-4.05 |
-4.61 |
| Acox1 |
Acyl-CoA oxydase 1, palmitoyl (peroxisomal) |
-2.10 |
-1.63 |
-4.27 |
| Cyp4a10 |
Cytochrome P450 4A10 |
-6.76 |
-2.46 |
NS |
| Cpy4a14 |
Cytochrome P450 4A14 |
-9.21 |
-3.09 |
NS |
| TCA cycle |
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| Aco2 |
Aconitase 2, mitochondrial |
-2.14 |
-1.82 |
NS |
| Idh2 |
Isocitrate dehydrogenase 2, mitochondrial |
-2.09 |
NS |
NS |
| Cholesterol catabolism |
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| Cyp7a1 |
Cholesterol 7α-hydroxylase |
-3.15 |
NS |
NS |
| Cyp39a1 |
Oxysterol 7α-hydroxylase |
-2.60 |
NS |
NS |
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S-scores were obtained as described in Material and methods and are proportional to fold changes. Negative S-scores indicate that the genes are more highly expressed in wild-type (WT) than in knockout (KO) mice, or in WT B6 than in WT D2 mice. Variations in the expression of genes involved in the tricarboxylic acid (TCA) cycle are provided for information. CoA, coenzyme A; NS, not significant. | ||||
Coppin et al. Genome Biology 2007 8:R221 doi:10.1186/gb-2007-8-10-r221 |
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