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Functional categories over-represented in clusters of genes similarly regulated by Hfe disruption in duodenum |
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| Category |
Term |
n |
EASE score |
|
|
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| Cluster 1 (209 Affy IDs [177 genes]) |
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| No functional category overrepresented |
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| Cluster 3 (141 Affy IDs [131 genes]) |
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| GOTERM_BP |
Defense response |
21 |
1.6 × 10-7 |
| GOTERM_BP |
Induction of apoptosis |
6 |
1.7 × 10-3 |
|
Affymetrix probesets in the different k-means clusters shown in Additional data file 2 were compared with Affymetrix MG-430 2.0 probe sets for over-representation of gene categories, using the DAVID (Database for Annotation, Visualization, and Integrated Discovery) functional annotation tool. The Category column shows the original database/resource from which the terms originate. The Term column indicates enriched terms associated with the gene list. The n column indicates the number of genes involved in the term. The expression analysis systematic explorer (EASE) score is a modified Fisher exact P value [51]. BP, biological process; GO, Gene Ontology. | |||
Coppin et al. Genome Biology 2007 8:R221 doi:10.1186/gb-2007-8-10-r221 |
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