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Genes differentially expressed between wild-type strains or regulated by Hfe deficiency, located within the chromosomal regions containing Hfe-modifiers, and with evidence for cis regulation |
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| Gene name |
Chromosome |
Position (Mb) |
Type |
Position of linkage peak (Mb) for cis regulator |
Max LRS for cis regulator |
|
|
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| Clca2 |
3 |
144.73 |
D |
144.70 to 144.94 |
46.7 |
| Lphn2 |
3 |
148.87 |
S |
149.36 to 151.27 |
15.5 |
| Uble1a |
7 |
15.49 |
S |
15.19 to 15.53 |
51.53 |
| Ckap1 |
7 |
29.93 |
S |
29.49 to 30.12 |
53.8 |
| Hamp1/Hamp2 |
7 |
30.63 |
L, S |
30.43 to 34.11 |
18.9 |
| Fxyd5 |
7 |
30.74 |
D |
34.41 to 34.62 |
15.2 |
| Gpsn2 |
8 |
86.46 |
S |
83.77 to 85.83 |
15.2 |
| Ddx39 |
8 |
86.61 |
L |
86.07 to 88.74 |
12.7 |
| 2410018C20Rik |
8 |
87.14 |
S |
86.07 to 88.74 |
20.6 |
| Ier2 |
8 |
87.55 |
L |
86.07 to 88.74 |
15.9 |
| Gadd45gip1 |
8 |
87.72 |
S |
86.07 to 88.74 |
116.4 |
| Prdx2 |
8 |
87.86 |
S |
83.77 to 85.83 |
36.1 |
| Pttg1 |
11 |
43.26 |
S |
42.87 to 44.25 |
68.9 |
| 5730409G07Rik |
11 |
45.79 |
S |
42.21 to 46.06 |
16.4 |
| 2900006B13Rik |
11 |
51.43 |
L, S |
50.95 to 53.90 |
38.9 |
| Tnip1 |
11 |
54.75 |
S |
50.95 to 53.90 |
60.6 |
| Sparc |
11 |
55.24 |
S |
55.24 to 55.92 |
26.1 |
| Guk1 |
11 |
59.00 |
S |
58.93 to 59.04 |
50.8 |
| Sat2 |
11 |
69.44 |
S |
69.42 to 70.27 |
133.2 |
| Mpdu1 |
11 |
69.47 |
S |
72.49 to 72.98 |
43.3 |
| Asgr2 |
11 |
69.91 |
S |
69.42 to 70.27 |
69.9 |
| Rabep1 |
11 |
70.66 |
L |
73.93 to 75.08 |
18.3 |
| Txnl5 |
11 |
72.02 |
S |
67.96 to 68.74 |
11.1 |
| Pafah1b1 |
11 |
74.49 |
L, S |
75.29 to 76.41 |
14.5 |
| Crk |
11 |
75.50 |
L |
76.76 to 76.83 |
10.5 |
| Ccl9 |
11 |
83.39 |
L, S |
88.48 to 89.36 |
36.9 |
| Bcas3 |
11 |
85.17 |
S |
89.57 to 89.92 |
12.2 |
| Dhx40 |
11 |
86.59 |
S |
83.52 to 88.25 |
36.8 |
| Scpep1 |
11 |
88.74 |
L, S |
83.52 to 88.25 |
39.2 |
| 9030617O03Rik |
12 |
101.18 |
S |
100.97 to 102.71 |
51.5 |
|
The Chromosome and Position columns indicate, respectively, the chromosome number and position (in megabases [Mb]) within one of the five Hfe-modifier intervals of the gene with expression variation. In the Type column, S indicates that expression differed between wild-type strains, D that expression was modulated by Hfe deficiency in duodenum, and L that expression was modulated by Hfe deficiency in liver. Max LRS indicates the maximum likelihood ratio statistic in favor of the cis regulator. Position of linkage peak for cis regulator and maximum LRS were retrieved from the WebQTL interface. | |||||
Coppin et al. Genome Biology 2007 8:R221 doi:10.1186/gb-2007-8-10-r221 |
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