Figure 3.

TFBSs used in the evolution simulation. PWMs of these TFBSs are taken from JASPAR [39], and their accession numbers are listed in the second column. The height of an individual letter in the motif logo represents the information content of each position in a motif. The motif logo plots were created by WebLogo [82]. The functional constraints on individual TFBSs used in the simulation are given.