Resolution:
## Figure 4.
Exponential relationship between E2F replacement turnover rate and sequence divergence
distance. The x-axis is the evolution divergence measured by the number of substitutions
per site, and the y-axis is the RTR of an E2F site in a descendent sequence. The points
are values observed from simulation, and lines are values predicted by the exponential
model given in equation 2.
(a) E2F replacement turnover rates observed in an evolution simulation starting from simulated
ancestral promoter sequences, where λ is 0.0832 and 0.0724 for fitting the mean and
median, respectively. (b) E2F replacement turnover rates observed in an evolution simulation starting from real
human promoter sequences, where λ is 0.0833 and 0.0755 for fitting the mean and median,
respectively.
Huang |