Surprising complexity of the ancestral apoptosis network1Burnham Institute for Medical Research, North Torrey Pines Road, La Jolla, CA 92037, USA 2School of Informatics, Indiana University, E.10th Street, Bloomington, IN 47408, USA 3Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, Gilman Drive, La Jolla, CA 92093, USA
Genome Biology 2007, 8:R226doi:10.1186/gb-2007-8-10-r226
Subject areas: Evolution, Genome studies, Bioinformatics Additional filesAdditional data file 1: This phylogeny was calculated using a Bayesian approach (MrBayes) based on a MAFFT alignment of Peptidase_C14 domains. Posterior probability values are shown for each branch (for detailed information, see Materials and methods). Species abbreviations: BRAFL, Branchiostoma floridae (amphioxus); BRARE, Brachydanio rerio (zebrafish); CAEBR, Caenorhabditis briggsae; CAEEL, Caenorhabditis elegans; CANFA, Canis familiaris (dog); CHICK, Gallus gallus (chicken); CIOIN, Ciona intestinalis (sea squirt); DROME, Drosophila melanogaster (fruit fly); FUGRU, Fugu rubripes (Japanese pufferfish); NEMVE, Nematostella vectensis (starlet sea anemone); STRPU, Strongylocentrotus purpuratus (purple sea urchin); TETNG, Tetraodon nigroviridis (green pufferfish); and XENTR, Xenopus tropicalis (western clawed frog). For a detailed list of protein sequences see Additional data file 4. Para-caspases are excluded from this phylogeny. Format: EPS Size: 1.5MB Download file Additional data file 2: Protein sequences for Figure 2 (phylogeny and domain organization of CED-4/Apaf-1 homologs). Format: PDF Size: 20KB Download file This file can be viewed with: Adobe Acrobat Reader Additional data file 3: Protein sequences for Figure 3 (phylogeny of the multi-motif Bcl-2 family). Format: PDF Size: 42KB Download file This file can be viewed with: Adobe Acrobat Reader Additional data file 4: Protein sequences for Additional data file 1 (phylogeny of the caspase family). Format: PDF Size: 61KB Download file This file can be viewed with: Adobe Acrobat Reader |


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