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Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo

Lixin Yang1, Jules R Kemadjou1, Christian Zinsmeister1, Matthias Bauer1, Jessica Legradi1, Ferenc Müller1, Michael Pankratz1, Jens Jäkel23 and Uwe Strähle1*

Author Affiliations

1 Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, Postfach 3640, 76021 Karlsruhe, Germany

2 Institute for Applied Computer Science, Forschungszentrum Karlsruhe, Postfach 3640, 76021 Karlsruhe, Germany

3 Institute for Measurement and Control Engineering, HTWK Leipzig, Postfach 30 11 66, 04251 Leipzig, Germany

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Genome Biology 2007, 8:R227  doi:10.1186/gb-2007-8-10-r227

Published: 25 October 2007

Additional files

Additional data file 1:

Embryos were exposed between 24 and 48 hpf and the morphological defects were scored at 72 hpf.

Format: EPS Size: 914KB Download file

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Additional data file 2:

Significant gene ontology groups affected by the toxicant are indicated in red.

Format: EPS Size: 1.8MB Download file

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Additional data file 3:

Significant gene ontology groups affected by the toxicant are indicated in red.

Format: EPS Size: 2.2MB Download file

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Additional data file 4:

Significant gene ontology groups affected by the toxicant are indicated in red.

Format: EPS Size: 2.6MB Download file

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Additional data file 5:

Significant gene ontology groups affected by the toxicant are indicated in red.

Format: EPS Size: 1.5MB Download file

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Additional data file 6:

Significant gene ontology groups affected by the toxicant are indicated in red.

Format: EPS Size: 2.2MB Download file

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Additional data file 7:

Significant gene ontology groups affected by the toxicant are indicated in red.

Format: EPS Size: 4.1MB Download file

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Additional data file 8:

Significant gene ontology groups affected by the toxicant are indicated in red.

Format: EPS Size: 768KB Download file

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Additional data file 9:

Significant gene ontology groups affected by the toxicant are indicated in red.

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Additional data file 10:

Summary of gene responses of embryos exposed to different concentrations of Cd.

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Additional data file 11:

Summary of gene responses of embryos exposed to different concentrations of MeHg.

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Additional data file 12:

Summary of gene responses of embryos exposed to different concentrations of TCDD.

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Additional data file 13:

ID, GeneBank accession number.

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Additional data file 14:

List of primers used in the RT-PCR experiments shown in Figure 4.

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