Additional data file 10.
Each page of the PDF contains a plot of the log2 ratios for clones (censored at ±0.3) on the long arm of chromosome 7 for five samples analyzed in  (samples S20, S30, S32, S40 and S60). The fitted loess curve for this genomic region has been overlaid in blue and the thresholds used in  to identify clones harboring CNVs are shown by horizontal dashed gray lines. On all five plots we can observe that the fitted loess curve has a trough at around 75 and 100 Mb (this is common to all samples - see Additional data file 6), suggesting that this is a technical artifact. Moreover, in all five plots a small number of clones in these regions have log2 ratios that are lower than the threshold and, consequently, they are flagged (almost certainly incorrectly) as harboring a CNV.
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Marioni et al. Genome Biology 2007 8:R228 doi:10.1186/gb-2007-8-10-r228