On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees

Tomàs Marques-Bonet¹ , Jesús Sànchez-Ruiz¹ , Lluís Armengol²^,7 , Razi Khaja³ , Jaume Bertranpetit¹^,7 , Núria Lopez-Bigas⁴ , Mariano Rocchi⁵ , Elodie Gazave¹ and Arcadi Navarro¹^,6^,7^,8

¹Unitat de Biologia Evolutiva Departament de Ciències Experimentals i de la Salut, Departament de Ciències Experimentals i de la Salut. Universitat Pompeu Fabra. Parc de Recerca Biomèdica de Barcelona. Dr. Aiguader 88. 08003 Barcelona. Catalonia, Spain

²Genes and Disease Program, Center for Genomic Regulation,. Parc de Recerca Biomèdica de Barcelona. Dr. Aiguader 88, 1. 08003 Barcelona. Catalonia, Spain

³The Center for Applied Genomics. The Hospital for Sick Children. MaRS Centre - East Tower. 101 College Street, Room 14-706. Toronto, Ontario. Canada

⁴Research Unit on Biomedical Informatics of IMIM/UPF. Parc de Recerca Biomèdica de Barcelona. Dr. Aiguader 88. 08003 Barcelona. Catalonia, Spain

⁵Dipartimento di Genetica e Microbiologia. Universita di Bari, Bari, Italy

⁶Institucio Catalana de Recerca i Estudis Avancats (ICREA) and Unitat de Biologia Evolutiva, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra. Parc de Recerca Biomèdica de Barcelona. Plaça Dr. Aiguader 88. 08003 Barcelona. Catalonia, Spain

⁷CIBER Epidemiología y Salud Pública (CIBERESP), Spain

⁸Population Genomics Node (GNV8) National Institute for Bioinformatics (INB), Spain

author email corresponding author email

Genome Biology 2007, 8:R230doi:10.1186/gb-2007-8-10-r230


Published:	30 October 2007

Subject areas: Evolution, Genome studies

Additional files

Additional data file 1:

Analysis of lineage-specific evolutionary rates and recombination rates for factors known to affect evolutionary rates and according to their position in relation to rearrangements as well as a comparison of evolutionary breakpoints between human and chimpanzee.

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