Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster

doi:10.1186/gb-2007-8-10-r231

Genome Biology

Volume 8
Issue 10

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Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster

Tatiana V Morozova¹^,2^,3 , Robert RH Anholt¹^,2^,4 and Trudy FC Mackay²^,4

¹Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA

²WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA

³Institute of Molecular Genetics RAS, Kurchatov Square, Moscow 123182, Russia

⁴Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA

author email corresponding author email

Genome Biology 2007, 8:R231doi:10.1186/gb-2007-8-10-r231


Published:	31 October 2007

Subject areas: Genetics, Physiology, Model organisms

Additional files

Additional data file 1:

Probe sets differentially expressed between selection lines at q < 0.001.

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Additional data file 2:

Probe sets with significant differences in contrast statements at p < 0.05.

Format: XLS Size: 874KB Download file

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Additional data file 3:

The 121 probe sets with larger than two-fold differences in transcript abundance between selection lines.

Format: XLS Size: 115KB Download file

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Additional data file 4:

Biological processes GO categories of genes in Additional data file 3.

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Additional data file 5:

Biological processes GO categories of genes in Additional data file 2.

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Additional data file 6:

Molecular function GO categories of genes in Additional data file 2.

Format: XLS Size: 1.4MB Download file

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Additional data file 7:

Common probe sets of differentially expressed genes from three artificially selected populations.

Format: XLS Size: 90KB Download file

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Additional data file 8:

Biological processes GO categories of genes in Additional data file 7.

Format: XLS Size: 63KB Download file

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Additional data file 9:

Common probe sets differentially expressed in response to exposure to ethanol in two experiments (artificial selection for alcohol sensitivity/resistant and tolerance development).

Format: XLS Size: 69KB Download file

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Additional data file 10:

Genes previously implicated in alcohol sensitivity in Drosophila melanogaster.

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Additional data file 11:

Drosophila probe sets of genes with human orthologues differentially expressed in alcoholics' brain regions.

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Additional data file 12:

Drosophila probe sets of genes that are differentially expressed in response to artificial selection and have murine orthologues associated with alcohol related phenotypes.

Format: XLS Size: 130KB Download file

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