Table 2

Functional tests of candidate genes

Line

Gene name

MET (SE)

p value

Human orthologue

Biological function

Canton S B

Control

5.4 (0.01)

NA

NA

NA

BG02818

BG02327

pipsqueak (psq)

3.5 (0.08)

5.75 (0.22)

<0.0001

0.1776

NA

Regulation of transcription, DNA-dependent

BG02845

Toll (Tl)

3.6 (0.09)

<0.0001

toll-like receptor 4*

Defense response, immune response, Toll signaling pathway

BG02317

BG01705

BG02624

CG9650

3.6 (0.10)

4.9 (0.18)

5.6 (0.16)

<0.0001

0.1118

0.6381

B-cell lymphoma/leukemia 11A*

Regulation of transcription from RNA polymerase II promoter, nucleic acid binding

BG02522

CG32560

3.8 (0.15)

<0.0032

DAB2 interacting protein*

Ras protein signal transduction, G-protein coupled receptor, MAPKKK cascade

BG01371

CG12505

4.3 (0.13)

0.0012

NA

Nucleic acid binding

BG02560

CG9674

4.3 (0.14)

0.0042

NA

Carbohydrate metabolism, amino acid biosynthesis

BG02210

BG02523

lamina ancestor (lama)

4.6 (0.10)

5.7 (0.36)

0.0014

0.6441

NP_775813, novel gene

Unknown

BG01037

β^ν integrin (βInt-ν)

4.6 (0.13)

0.0014

NA

Signal transduction, defense response

BG02812

BG02830

Lipid storage droplet-2 (Lsd-2)

4.7 (0.12)

5.52 (0.23)

0.0083

0.7909

Adipose differentiation-related protein

Lipid transport, sequestering of lipid

BG02518

CG8920

4.7 (0.11)

0.0025

Tudor domain containing protein 7

Nucleic acid binding

BG00987

smell impaired 35A (smi35A)

5.4 (0.14)

0.9859

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4

Olfactory behavior, response to chemical stimulus, nervous system development

BG01008

CG11133

5.6 (0.09)

0.6816

NA

Unknown

BG02207

BG2034

lilliputian (lilli)

5.8 (0.11)

6.0 (0.28)

0.0905

0.1549

Fragile X mental retardation 2 protein*

Regulation of transcription, DNA-dependent

BG02114

BG01509

CG30015

6.2 (0.17)

5.6 (0.31)

0.0120

0.4924

NA

Unknown

BG02055

little imaginal discs (lid)

6.4 (0.11)

0.0283

Jumonji, AT rich interactive domain 1A

Regulation of transcription, DNA dependent

BG01081

Glutamate oxaloacetate transaminase 1 (Got1)

6.5 (0.10)

0.0048

Glutamic-oxaloacetic transaminase 1

Amino acid metabolism, biosynthesis

BG01013

Poly(ADP-ribose) glycohydrolase (Parg)

6.5 (0.28)

0.0137

Poly(ADP-ribose) glycohydrolase*

Carbohydrate metabolism, glycolysis

BG01389

Laminin A (LanA)

6.8 (0.15)

0.0020

laminin, alpha-5

Proteolysis, signal transduction, central nervous system development

BG02420

CG5946

6.9 (0.15)

<0.0001

Cytochrome b5 reductase 3*

Fatty acid desaturation, cholesterol metabolism

BG01144

CG17646

7.0 (0.16)

0.0002

NA

Lipid metabolism, nucleotide binding

BG02731

BG02501

longitudinals lacking (lola)

7.1 (0.11)

5.8 (0.31)

<0.0001

0.5457

Zinc finger and BTB domain containing protein 3

Regulation of transcription from RNA polymerase II promoter, nervous system development

BG02276

CG7832

7.6 (0.13)

<0.0001

NA

Protein binding

BG02365

Malic enzyme (Men)

7.7 (0.24)

<0.0001

Malic enzyme 1, NADP(+)-dependent

Malate metabolism, carbohydrate metabolism

BG02180

nuclear fallout (nuf)

8.1 (0.18)

<0.0001

RAB11 family interacting protein 4

Protein binding, actin cytoskeleton reorganization

BG01342

Kinesin-73 (Khc-73)

8.1 (0.21)

<0.0001

kinesin family member 13A

Protein targeting, exocytosis

BG02405

BG00525

corto

8.2 (0.21)

5.2 (0.21)

0.0086

0.2390

NA

Cell cycle, RNA polymerase II transcription factor activity, protein binding

BG02128

lethal (1) G0007 (l(1)G0007)

8.3 (0.13)

<0.0001

DEAH-box protein 38

Nuclear mRNA splicing, via spliceosome; nucleic acid binding

BG01672

CG14591

8.7 (0.20)

<0.0001

Transmembrane protein 164

Unknown

BG01989

visgun (vsg)

8.8 (0.19)

<0.0001

Transmembrane protein 123*

Learning and/or memory, olfactory learning

BG00291

retinal degeneration B (rdgB)

8.9 (0.19)

<0.0001

phosphatidylinositol transfer protein, membrane-associated 2

Lipid metabolism, sensory perception of smell, calcium ion transport

BG01536

Beadex (Bx)

8.9 (0.19)

<0.0001

LIM-only protein 1*

Nervous system development, regulation of transcription from RNA polymerase II promoter

BG01733

CG6175

9.0 (0.20)

<0.0001

NA

Unknown

BG01214

sugarless (sgl)

9.2 (0.20)

<0.0001

UDP-glucose dehydrogenase

Lipid metabolism, cell surface receptor linked signal transduction

BG02679

BG00990

wing blister (wb)

9.2 (0.15)

7.2 (0.13)

<0.0001

0.0093

laminin, alpha 2*

Signal transduction

BG01127

muscleblind (mbl)

9.6 (0.17)

<0.0001

muscleblind-like 1, isoform b*

Peripheral nervous system development, response to stimulus, nucleic acid binding

Lines that survived Bonferroni significance threshold = 0.0011 are indicated in bold font. Human orthologues have homology scores of >0.98 and bootstrap scores of >83% [86]. *Human orthologues associated with known diseases. NA, not applicable.

Morozova et al. Genome Biology 2007 8:R231   doi:10.1186/gb-2007-8-10-r231