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Highly Accessed Review

Chromatin, gene silencing and HIV latency

Hoi-Ping Mok and Andrew ML Lever*

Author Affiliations

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.

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Genome Biology 2007, 8:228  doi:10.1186/gb-2007-8-11-228

Published: 23 November 2007

Abstract

One of the cellular defenses against virus infection is the silencing of viral gene expression. There is evidence that at least two gene-silencing mechanisms are used against the human immuno-deficiency virus (HIV). Paradoxically, this cellular defense mechanism contributes to viral latency and persistence, and we review here the relationship of viral latency to gene-silencing mechanisms.