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Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender

Xiangru Xu1, Ming Zhan2, Wenzhen Duan1, Vinayakumar Prabhu2, Randall Brenneman1, William Wood2, Jeff Firman2, Huai Li2, Peisu Zhang1, Carol Ibe1, Alan B Zonderman2, Dan L Longo3, Suresh Poosala2, Kevin G Becker2 and Mark P Mattson1*

Author Affiliations

1 Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA

2 Research Resources Branch, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA

3 Laboratory of Immunology, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA

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Genome Biology 2007, 8:R234  doi:10.1186/gb-2007-8-11-r234

Published: 7 November 2007

Additional files

Additional File 1:

Figure S1 shows one feature of aging that was shared among CNS regions, namely, the decline of energy metabolism. Figure S2 shows age-related changes in responsiveness of the hippocampal transcriptome to CR in males and females. Figure S3a-3f shows chromosome mapping of CNS age- and diet-responsive genes and loci. Figure S4 shows age-dependent gene expression variation analysis. Table S6 lists the perturbation probabilities of UPS, Wnt, and WRN pathways in different sexes of CNS regions during aging and in response to CR. Overview Of DIANE 1.0 provides an outline of this program. PathwayPro describes the PathwayPro computational tool Gene-specific primers used for Real-Time PCR analyses and microarray quality validation lists the primers for genes validated by quantitative RT-PCR. Table S2aP2-6 lists genes of mouse CNS age-related gene expression patterns 2-6. Table S2b lists mouse CNS AAGs. Table S3 lists functional categories of known mouse CNS AAGs. Stable 1 shows genes consistently responsive to CR across advancing age in mouse CNS. Table S4a-6M-16M-24M lists CR responsive genes of 6M-16M-24M mouse CNS. Table S4c lists the impact of CR on the reversion of AAG expression. Table S5a lists age-dependent differentially expressed genes in males and females. Table S5b,c lists genes differentially affected by CR in males and females. Table S5d lists age-responsive genes that were reverted by CR in males compared to females. Table S7a-d lists results of cross comparison between this study and previous published data.

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