Figure 4.

Procedure for estimating MI significance between alignment columns. See the main text and Materials and methods for a complete description of the procedure used to estimate the statistical significance of MI scores between columns in a multiple sequence alignment in order to evaluate riboswitch secondary structures and predict new base-base interactions.

Barrick and Breaker Genome Biology 2007 8:R239   doi:10.1186/gb-2007-8-11-r239
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