Genome Biology

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Open Access Research

GeneChip analysis of human embryonic stem cell differentiation into hemangioblasts: an in silico dissection of mixed phenotypes

Shi-Jiang Lu1, Jennifer A Hipp2, Qiang Feng1, Jason D Hipp2, Robert Lanza1,2 and Anthony Atala2*

Author Affiliations

1 Advanced Cell Technology, Worcester, MA 01605, USA

2 Institute of Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA

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Genome Biology 2007, 8:R240 doi:10.1186/gb-2007-8-11-r240

Published: 13 November 2007

Additional files

Additional data file 1:

GenMAPP generated embryonic stem cell pathway that corresponds to genes enriched in ESs (green), EBs (orange) and BCs (red) with epithelial cells as a baseline.

Format: EPS Size: 2.5MB Download file

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Additional data file 2:

GATA1 interacts with other nuclear genes such as TAL1, LMO2, and KLF1, which induceeythropoetic genes such as the hemoglobin family (HBG1, HBG2, HBE, HBB, and HBZ), and those involved in heme synthesis (ALAS2).

Format: EPS Size: 12.1MB Download file

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Additional data file 3:

Genes that are down-regulated upon differentiation of ESCs into EBs.

Format: XLS Size: 24KB Download file

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Additional data file 4:

Genes that are down-regulated upon differentiation of ESCs into BCs.

Format: XLS Size: 75KB Download file

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Additional data file 5:

Genes that are up-regulated upon differentiation of ESCs into EBs.

Format: XLS Size: 37KB Download file

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Additional data file 6:

Genes that are down-regulated upon differentiation of EBs into BCs.

Format: XLS Size: 38KB Download file

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Additional data file 7:

Genes that are up-regulated upon differentiation of EBs into BCs.

Format: XLS Size: 23KB Download file

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Additional data file 8:

Genes that are up-regulated upon differentiation of ESCs into BCs.

Format: XLS Size: 27KB Download file

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Additional data file 9:

Genes that are up-regulated in ESCs when compared to breast epithelia.

Format: XLS Size: 262KB Download file

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Additional data file 10:

Genes that are up-regulated in EBs when compared to breast epithelia.

Format: XLS Size: 123KB Download file

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Additional data file 11:

Genes that are up-regulated in BCs when compared to breast epithelia.

Format: XLS Size: 328KB Download file

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Additional data file 12:

Genes that are up-regulated in BCs when compared to leukocytes.

Format: XLS Size: 299KB Download file

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Additional data file 13:

Genes that are up-regulated in BCs when compared to endothelial cells.

Format: XLS Size: 135KB Download file

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Additional data file 14:

Genes that are up-regulated in BCs when compared to stromal cells.

Format: XLS Size: 450KB Download file

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Additional data file 15:

CEL file of undifferentiated ESCs, embryonic stem cell line H1-GFP, that were hybridized to human U133 Plus 2.0 arrays (Affymetrix, Inc.)

Format: ZIP Size: 3.9MB Download file

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Additional data file 16:

CEL file of day 3.5 EBs, derived from H1, that were hybridized to human U133 Plus 2.0 arrays (Affymetrix, Inc.)

Format: ZIP Size: 4.1MB Download file

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Additional data file 17:

CEL file of BCs, derived from H1, that were hybridized to human U133 Plus 2.0 arrays (Affymetrix, Inc.).

Format: ZIP Size: 4.4MB Download file

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Additional data file 18:

CEL file of undifferentiated ESCs from embryonic stem cell line H9, that were hybridized to human U133 Plus 2.0 arrays (Affymetrix, Inc.).

Format: ZIP Size: 4.3MB Download file

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Additional data file 19:

CEL file of day 3.5 EBs, derived from H9, that were hybridized to human U133 Plus 2.0 arrays (Affymetrix, Inc.).

Format: ZIP Size: 4.3MB Download file

Open Data

Additional data file 20:

CEL file of BCs, derived from H1, that were hybridized to human U133 Plus 2.0 arrays (Affymetrix, Inc.).

Format: ZIP Size: 4.3MB Download file

Open Data