Table 1

Losses in Tribolium and its (Coleoptera/Diptera) ancestor mapped to pathways using human orthologs

Pathway

Source

Genes

Total

Only in beetle

Significance

Neuroactive ligand-receptor interaction

KEGG

NPFFR1, NPFFR2, BZRP, TSPO, GALR1, GALR2, GALR3

6

6

0.099

ABC transporters - general

KEGG

ABCA1, ABCA4, ABCA12, ABCC5, ABCC12

5

3

4.73E-005*

Oxidative phosphorylation

KEGG

ATP6V0E, UCRC (7.2 kDa), NDUFA7, COX7C

4

4

0.04

Cell cycle

KEGG

CDC7, CCNE1, DBF4

3

3

0.12

Folate biosynthesis/starch and sucrose metabolism

KEGG

RAD54B, SETX

2

2

0.06

Alkaloid biosynthesis II

KEGG

DDHD1, SLC27A2

2

0

0.02^†

Regulation of actin cytoskeleton

KEGG

FGD1, IQGAP1

2

0

Cholera - infection

KEGG

ATP6V0E1, TRIM23

2

1

0.06

Purine metabolism

KEGG

PDE1C, POLR2L

2

2

0.49

Ribosome

KEGG

RPL29, RPL39

2

2

0.53

Neurodegenerative disorders

KEGG

BCL2L1, NGFR

2

0

0.06

Propanoate metabolism

KEGG

MLYCD, SLC27A2

2

0

0.07

Methionine metabolism

KEGG

DNMT1, DNMT3B

2

0

Oxidative stress induced gene expression via Nrf2

Biocarta

HMOX1, NGFR

2

1

0.02^†

The statistical significance of the coordinated losses of at least two genes per pathway was calculated using hypergeometric test (* p < 0.01,^†p < 0.05).

Wyder et al. Genome Biology 2007 8:R242   doi:10.1186/gb-2007-8-11-r242