Genome Biology

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Using protein complexes to predict phenotypic effects of gene mutation

Hunter B Fraser* and Joshua B Plotkin

Genome Biology 2007, 8:R252 doi:10.1186/gb-2007-8-11-r252

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Research article   Open Access

Functional and evolutionary correlates of gene constellations in the Drosophila melanogaster genome that deviate from the stereotypical gene architecture

Shuwei Li, Ching-Hua Shih, Michael H Kohn BMC Genomics 2010, 11:322 (24 May 2010)

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Discovering cancer genes by integrating network and functional properties

Li Li, Kangyu Zhang, James Lee, Shaun Cordes, David P Davis, Zhijun Tang BMC Medical Genomics 2009, 2:61 (19 September 2009)

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Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network

Bolan Linghu, Evan S Snitkin, Zhenjun Hu, Yu Xia, Charles DeLisi Genome Biology 2009, 10:R91 (3 September 2009)

An evidence-weighted functional-linkage network of human genes reveals associations among diseases that share no known disease genes and have dissimilar phenotypes

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Linking genes to diseases: it's all in the data

Nicki Tiffin, Miguel A Andrade-Navarro, Carolina Perez-Iratxeta Genome Med 2009, 1:77 (7 August 2009)

Computational approaches to disease-gene associations, especially those that use phenotype ontologies, can help to prioritize the most likely candidate genes.

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Translational disease interpretation with molecular networks

Anaïs Baudot, Gonzalo Gómez-López, Alfonso Valencia Genome Biology 2009, 10:221 (29 June 2009)

The integration of medical information into gene and protein networks could lead to a better understanding of complex diseases.

Research article   Open Access

An evolutionary and structural characterization of mammalian protein complex organization

Philip Wong, Sonja Althammer, Andrea Hildebrand, Andreas Kirschner, Philipp Pagel, Bernd Geissler, Pawel Smialowski, Florian Blöchl, Matthias Oesterheld, Thorsten Schmidt, Normann Strack, Fabian J Theis, Andreas Ruepp, Dmitrij Frishman BMC Genomics 2008, 9:629 (23 December 2008)