Significant functional modules (modules A-D). Straight lines represent validated protein-protein interactions, curved lines represent demonstrated genetic interactions (black bullets, predictive interactions; white bullets, protective interactions). Circles with gene names represent the gene encoding the protein of the interaction. Boxes are the marker regions shown to be involved in the genetic interactions and in which the genes are located.
Bergholdt et al. Genome Biology 2007 8:R253 doi:10.1186/gb-2007-8-11-r253