Table 1

Marginal markers.

χ2 (2 d.f.)

P value

Position on chromosome in cM

Confirmed from genome scan (LOD - 1 interval) or other references


Total data set

TNFA

142.0

1.5 × 10-32

47

6p21 (46-48 cM) [25]

D6S273

77.0

7.0 × 10-18

45

D6S291

58.2

2.2 × 10-13

49.5

D6S276

34.8

3.4 × 10-8

44.4

D6S260

27.1

8.2 × 10-7

29.9

D6S286

21.4

1.6 × 10-5

89.8

D6S283

18.3

0.0001

109.2

[26]

D6S470

15.2

0.0005

18.2

D6S300

10.6

0.005

103.5

[26]

D17S798

9.8

0.007

53.4

D2S152

8.7

0.013

188.1

2q31-33 (177-204 cM) [25]

D2S125

7.0

0.03

260.6

D9S175

6.3

0.043

70.3

D8S261

6.1

0.048

37.0

D4S403

6.1

0.048

25.9

Selected markers

UK/US subset

D2S389

13.1

0.001

190

2q31-33 (177-204 cM) [25]

D16S769

9.4

0.009

50.6

16p12-q11.1 (26-71 cM) [25]

Th1

9.0

0.011

5.9

11p15.5 (0-14 cM) [25]

D16S289

8.1

0.017

105

16q22-q24 (100-121 cM) [25]

D10S183

6.7

0.035

60.6

10p14-q11 (52-66 cM) [25]

SCAND subset

D21S270

6.4

0.039

38.1

[27]


Markers of predictive value for T1D identified by decision tree analysis on T1D genome scan data from 1321 affected sib pair families. Markers identified in the total data set are ranked according to significance level (P < 0.05). Markers from data subsets are 'selected markers' and were selected on basis of whether they confirm loci from the latest T1D genome scan [25] or other references [26; 27]. D.f. = degrees of freedom.

Bergholdt et al. Genome Biology 2007 8:R253   doi:10.1186/gb-2007-8-11-r253

Open Data