Table 1 |
||||
|
Marginal markers. |
||||
|
χ2 (2 d.f.) |
P value |
Position on chromosome in cM |
Confirmed from genome scan (LOD - 1 interval) or other references |
|
|
|
||||
|
Total data set |
||||
|
TNFA |
142.0 |
1.5 × 10-32 |
47 |
6p21 (46-48 cM) [25] |
|
D6S273 |
77.0 |
7.0 × 10-18 |
45 |
|
|
D6S291 |
58.2 |
2.2 × 10-13 |
49.5 |
|
|
D6S276 |
34.8 |
3.4 × 10-8 |
44.4 |
|
|
D6S260 |
27.1 |
8.2 × 10-7 |
29.9 |
|
|
D6S286 |
21.4 |
1.6 × 10-5 |
89.8 |
|
|
D6S283 |
18.3 |
0.0001 |
109.2 |
[26] |
|
D6S470 |
15.2 |
0.0005 |
18.2 |
|
|
D6S300 |
10.6 |
0.005 |
103.5 |
[26] |
|
D17S798 |
9.8 |
0.007 |
53.4 |
|
|
D2S152 |
8.7 |
0.013 |
188.1 |
2q31-33 (177-204 cM) [25] |
|
D2S125 |
7.0 |
0.03 |
260.6 |
|
|
D9S175 |
6.3 |
0.043 |
70.3 |
|
|
D8S261 |
6.1 |
0.048 |
37.0 |
|
|
D4S403 |
6.1 |
0.048 |
25.9 |
|
|
Selected markers |
||||
|
UK/US subset |
||||
|
D2S389 |
13.1 |
0.001 |
190 |
2q31-33 (177-204 cM) [25] |
|
D16S769 |
9.4 |
0.009 |
50.6 |
16p12-q11.1 (26-71 cM) [25] |
|
Th1 |
9.0 |
0.011 |
5.9 |
11p15.5 (0-14 cM) [25] |
|
D16S289 |
8.1 |
0.017 |
105 |
16q22-q24 (100-121 cM) [25] |
|
D10S183 |
6.7 |
0.035 |
60.6 |
10p14-q11 (52-66 cM) [25] |
|
SCAND subset |
||||
|
D21S270 |
6.4 |
0.039 |
38.1 |
[27] |
|
|
||||
|
Markers of predictive value for T1D identified by decision tree analysis on T1D genome scan data from 1321 affected sib pair families. Markers identified in the total data set are ranked according to significance level (P < 0.05). Markers from data subsets are 'selected markers' and were selected on basis of whether they confirm loci from the latest T1D genome scan [25] or other references [26; 27]. D.f. = degrees of freedom. |
||||
|
Bergholdt et al. Genome Biology 2007 8:R253 doi:10.1186/gb-2007-8-11-r253 |
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