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Statistically significant genomic interactions |
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| First level |
Second level |
Pearson's χ2 (2 d.f.) |
P value |
|
|
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| TNFA = 2 |
D4S403 |
9.10 |
0.011 |
| TNFA = 2 |
D2S177 |
7.33 |
0.026 |
| TNFA = 2 |
D1S229 |
6.88 |
0.032 |
| TNFA = 1 |
D11S910 |
11.82 |
0.0027 |
| TNFA = 1 |
D13S170 |
6.84 |
0.033 |
| TNFA = 1 |
D16S287 |
6.63 |
0.036 |
| D17S798 = 2 |
D2P25 |
6.41 |
0.041 |
| D17S798 = 1 |
D5S429 |
7.08 |
0.029 |
| D17S798 = 1 |
D1S197 |
6.94 |
0.031 |
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Markers corresponding to the first and second level of each significant interaction, as well as Pearson χ2 statistics and corresponding P value, are shown. Affected sibling pairs (ASPs) genotyped for the TNFA and D17S798 marker were as follows (non-T1D sibling pairs were simulated to be twice the number of ASPs for each group): TNFA = 2, 520 ASP and 1,040 non-T1D sibling pairs; TNFA = 1, 206 ASP and 412 non-T1D sibling pairs; D17S798 = 2, 136 ASP and 272 non-T1D sibling pairs; D17S798 = 1, 254 ASP and 508 non-T1D sibling pairs. | |||
Bergholdt et al. Genome Biology 2007 8:R253 doi:10.1186/gb-2007-8-11-r253 |
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