Table 2

Statistically significant genomic interactions

First level

Second level

Pearson's χ2 (2 d.f.)

P value


TNFA = 2

D4S403

9.10

0.011

TNFA = 2

D2S177

7.33

0.026

TNFA = 2

D1S229

6.88

0.032

TNFA = 1

D11S910

11.82

0.0027

TNFA = 1

D13S170

6.84

0.033

TNFA = 1

D16S287

6.63

0.036

D17S798 = 2

D2P25

6.41

0.041

D17S798 = 1

D5S429

7.08

0.029

D17S798 = 1

D1S197

6.94

0.031


Markers corresponding to the first and second level of each significant interaction, as well as Pearson χ2 statistics and corresponding P value, are shown. Affected sibling pairs (ASPs) genotyped for the TNFA and D17S798 marker were as follows (non-T1D sibling pairs were simulated to be twice the number of ASPs for each group): TNFA = 2, 520 ASP and 1,040 non-T1D sibling pairs; TNFA = 1, 206 ASP and 412 non-T1D sibling pairs; D17S798 = 2, 136 ASP and 272 non-T1D sibling pairs; D17S798 = 1, 254 ASP and 508 non-T1D sibling pairs.

Bergholdt et al. Genome Biology 2007 8:R253   doi:10.1186/gb-2007-8-11-r253

Open Data