Table 1

Co-receptors and signal transducers in the Nogo-A-NogoR interaction

Molecular region/interactor

Function/interaction

Reference(s)

NogoA-24

Increases binding affinity of Nogo-A to Nogo receptor (NogoR); binds NogoR directly

[15]

Δ20

Mediates fibroblast and growth cone collapse independently of NogoR

[16]

p75NTR

Neurotrophin receptor; binds NogoR and mediates inhibition of neurite outgrowth via myelin-associated inhibitors

[72,73]

LINGO-1

Binds NogoR; activates Rho in complex with p75 and NogoR; mediates Nogo66-induced neurite outgrowth inhibition

[74,75]

TAJ/TROY

Binds NogoR, activates Rho in complex with LINGO-1 and NogoR; absence attenuates myelin inhibition of neurite outgrowth

[76,77]

EGFR

Kinase activity required for neurite outgrowth but EGFR does not bind NogoR

[78]

Yang and Strittmatter Genome Biology 2007 8:234   doi:10.1186/gb-2007-8-12-234