Table 2

Enriched GO biological process categories for self-synergistic E2F1 and NFAT from between-TFBS distance 20 bp to 90 bp

E2F1

NFAT



Distance

No. of genes

Function categories

No. of genes

Function categories


D20

16

Cell cycle (0.07/0.09)

72

Homophilic cell adhesion (0.03/0.01)

D30

31

Sterol metabolism (0.004/0.004)

119

Homophilic cell adhesion (0.02/0.001)

Immune response (0.06/0.003)

Response to biotic stimulus (0.06/0.01)

Regulation of T cell activation (0.04/0.02)

Regulation of lymphocyte activation (0.07/0.002)

D40

49

Cell cycle (0.02/0.007)

166

Homophilic cell adhesion (0.04/0.006)

Sterol metabolism (0.04/0.01)

Immune response (0.04/0.008)

Nucleotide and nucleic acid metabolism (0.04/0.07)

Response to biotic stimulus (0.06/0.03)

Regulation of T cell activation (0.07/0.03)

D50

64

Sterol metabolism (0.01/0.02)

205

Homophilic cell adhesion (0.01/0.0006)

Cell cycle (0.005/0.02)

Immune response (0.08/0.03)

Nucleotide and nucleic acid metabolism (0.01/0.02)

D60

72

Cell cycle (0.002/0.009)

255

Immune response (0.03/0.002)

Sterol metabolism (0.001/0.01)

Homophilic cell adhesion (0.03/0.002)

Nucleotide and nucleic acid metabolism (0.008/0.02)

Response to biotic stimulus (0.09/0.01)

Regulation of lymphocyte activation (0.06/0.02)

Regulation of T cell activation (0.03/0.07)

Cell-substrate adhesion (0.005/0.01)

D70

83

Cellular physiological process (0.002/0.02)

300

Homophilic cell adhesion (0.002/0.0005)

Cell cycle (0.005/0.02)

Immune response (0.01/0.01)

Nucleotide and nucleic acid metabolism (0.02/0.04)

Response to biotic stimulus (0.05/0.08)

Sterol metabolism (0.002/0.003)

Regulation of lymphocyte activation (0.05/0.02)

Cell-substrate adhesion (0.008/0.02

Regulation of T cell activation (0.04/0.009)

D80

99

Nucleotide and nucleic acid metabolism (0.006/0.008)

341

Homophilic cell adhesion (0.0009/0.00001)

Cell cycle (0.001/0.03)

Immune response (0.02/0.0004)

Sterol metabolism (0.003/0.004)

Response to biotic stimulus (0.07/0.004)

Cellular physiological process (0.001/0.01)

Regulation of lymphocyte activation (0.03/0.03)

Cell-substrate adhesion (0.01/0.02)

D90

107

Nucleotide and nucleic acid metabolism (0.003/0.003)

392

Homophilic cell adhesion (0.0001/0.000001)

Cell cycle (0.002/0.06)

Immune response (0.04/0.0008)

Sterol metabolism (0.004/0.006)

Regulation of lymphocyte activation (0.05/0.04)

Cellular physiological process (0.001/0.006)

Response to biotic stimulus (0.06/0.009)

Cell-substrate adhesion (0.02/0.04)


The number of overlapping orthologous human and mouse genes whose promoters have at least two TF binding sites within certain distance constraints (for example, D20 for a between-TFBS distance of 20 bp) is listed under "No. of genes". The statistical significances of commonly enriched biological process categories from both human and mouse genes are listed in parentheses (p value mouse/p value human).

Hu et al. Genome Biology 2007 8:R257   doi:10.1186/gb-2007-8-12-r257

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