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Function annotation for 51 homotypic TF combinations |
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| TFs |
GO biological process categories |
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| AP3 |
Cell adhesion; cellular localization; cellular process; extracellular matrix organization and biogenesis; innate immune response; intracellular transport; second-messenger-mediated signaling |
| CAAT* |
Cell cycle; cell division [36]; cell organization and biogenesis; chromosome organization and biogenesis; DNA-dependent DNA replication; nucleobase, nucleoside, nucleotide and nucleic acid metabolism; protein localization; steroid biosynthesis |
| CACBINDING PROTEIN |
Calcium ion transport; cellular process; intracellular signaling cascade; morphogenesis; nervous system development; organ development; regulation of signal transduction |
| CEBPB |
Cellular carbohydrate metabolism |
| CETSP154 |
Cell organization and biogenesis; cellular localization; cellular process; organelle organization and biogenesis; protein localization; ribosome biogenesis; ubiquitin cycle; vesicle-mediated transport |
| CETS168 |
Cellular physiological process |
| CP2 |
N/A |
| CREB |
N/A |
| DBP |
Apoptosis; cell adhesion; endocytosis; innate immune response; intracellular signaling cascade; lipid metabolism; phosphate transport; protein kinase cascade; response to endogenous stimulus; RNA processing |
| DEAF1 |
N/A |
| DELTAEF1 |
Cell adhesion |
| E12 |
N/A |
| E2F1* |
Cell cycle [25-28]; cholesterol metabolism; nucleobase, nucleoside, nucleotide and nucleic acid metabolism; sterol metabolism |
| EGR* |
Apoptosis; brain development; cell cycle; cell proliferation; central nervous system development; development [49]; endocytosis; enzyme linked receptor protein signaling pathway; galactose metabolism; intracellular signaling cascade; metal ion transport; nervous system development [49]; protein amino acid phosphorylation; protein kinase cascade; small GTPase mediated signal transduction; synaptic transmission; transcription [37]; ubiquitin cycle |
| ETF* |
Cell cycle; cell proliferation; cellular lipid metabolism; central nervous system development; dephosphorylation; endocytosis; enzyme linked receptor protein signaling pathway; gluconeogenesis; heart development; hexose biosynthesis; intracellular signaling cascade; muscle development; neurite morphogenesis [38]; programmed cell death; protein kinase cascade; regulation of nucleocytoplasmic transport; response to DNA damage stimulus; small GTPase mediated signal transduction |
| FAC1 |
Cell adhesion; cell cycle; cellular lipid metabolism; endocytosis; I-kappaB kinase/NF-kappaB cascade; intracellular signaling cascade, via spliceosome; proteolysis; secretion. carbohydrate metabolism; DNA repair; nuclear import; protein kinase cascade; protein localization; response to endogenous stimulus; RNA splicing; ubiquitin cycle; vesicle-mediated transport; cytoplasm organization and biogenesis; innate immune response; endoplasmic reticulum to Golgi vesicle-mediated transport; microtubule cytoskeleton organization and biogenesis; wound healing; protein amino acid glycosylation |
| FOX |
N/A |
| FREAC7 |
N/A |
| GATA1 |
N/A |
| GC* |
Apoptosis [35]; cell proliferation [35]; actin cytoskeleton organization and biogenesis; cell cycle; cellular lipid metabolism; central nervous system development; endocytosis; enzyme linked receptor protein signaling pathway; endoplasmic reticulum to Golgi vesicle-mediated transport; gluconeogenesis; hexose biosynthesis; muscle development; nervous system development; Notch signaling pathway; nucleocytoplasmic transport; protein kinase cascade; small GTPase mediated signal transduction; synaptic transmission; transmembrane receptor protein tyrosine kinase signaling pathway; ubiquitin cycle; vesicle-mediated transport |
| HELIOSA |
Cellular physiological process; development; homophilic cell adhesion; regulation of metabolism |
| HNF1* |
Organic anion transport [39]; innate immune response |
| HNF3B |
Lipid metabolism; DNA metabolism |
| IRF7* |
Immune response [40] |
| KROX* |
Actin cytoskeleton organization and biogenesis; cell cycle; enzyme linked receptor protein signaling pathway; intracellular signaling cascade; nervous system development [50]; phosphate metabolism; regulation of neurotransmitter levels; small GTPase mediated signal transduction; system development; ubiquitin cycle |
| LBP1* |
Apoptosis [51]; cellular process; intracellular signaling cascade; protein amino acid phosphorylation; protein kinase cascade |
| LDSPOLYA |
Development; aromatic amino acid family metabolism; intracellular signaling cascade |
| LEF1TDF1 |
N/A |
| LFA1 |
N/A |
| MAZ* |
Apoptosis; brain development; cell adhesion; cell cycle; cell differentiation; endocytosis; enzyme linked receptor protein signaling pathway; intracellular signaling cascade; muscle development [41]; nervous system development; development [41]; protein amino acid phosphorylation; protein kinase cascade; regulation of actin filament length; small GTPase mediated signal transduction; Wnt receptor signaling |
| MINI19 |
N/A |
| MMEF2 |
N/A |
| MYCMAX |
Cellular metabolism; macromolecule metabolism |
| MZF1* |
Cell proliferation [52]; cell adhesion; cell cycle; cell differentiation; cell-cell signaling; enzyme linked receptor protein signaling pathway; hemopoiesis [52]; metal ion transport; nervous system development; neurotransmitter secretion; organ development; regulated secretory pathway; regulation of transcription, DNA-dependent; skeletal development; synaptic transmission; Wnt receptor signaling pathway |
| NFAT* |
Immune response [29-31]; homophilic cell adhesion; organ development |
| NMYC |
Cellular physiological process |
| NRF2* |
Organelle organization and biogenesis [42]; cellular physiological process; protein transport |
| OCT1 |
Apoptosis; cell-cell adhesion; cellular physiological process; protein transport |
| OSF2 |
N/A |
| PAX4 |
Cell proliferation; enzyme linked receptor protein signaling pathway; gamma-aminobutyric acid signaling pathway; inflammatory response; programmed cell death; regulation of kinase activity |
| PIT1 |
Proteolysis |
| PU1 |
Cell adhesion; regulation of kinase activity; regulation of transferase activity |
| S8* |
Development [46] |
| SP1* |
Cell differentiation [53]; cell proliferation [53]; apoptosis [35]; cell adhesion; cell cycle; cell-cell signaling; cellular lipid metabolism; central nervous system development; endocytosis; nervous system development; neurogenesis; nucleocytoplasmic transport; organelle organization and biogenesis; phosphate metabolism; protein kinase cascade; response to endogenous stimulus; Rho protein signal transduction; small GTPase mediated signal transduction; synaptic transmission; transcription from RNA polymerase II promoter; transmembrane receptor protein tyrosine kinase signaling pathway; ubiquitin cycle; vesicle-mediated transport |
| SRF |
N/A |
| SRY |
Cell adhesion; cellular process; intracellular signaling cascade; mRNA processing; organic acid metabolism; response to DNA damage stimulus; RNA metabolism; RNA splicing; steroid metabolism |
| TBP |
Protein transport; establishment of protein localization; RNA processing |
| TFIII* |
Cell adhesion; cell differentiation; cell organization and biogenesis; chromatin modification; enzyme linked receptor protein signaling pathway; intracellular signaling cascade; nervous system development; organ development; protein kinase cascade; protein modification; transcription, DNA-dependent [54] |
| XVENT1 |
Cell cycle; cell growth; cell proliferation; cellular biosynthesis; establishment of cellular localization; inflammatory response; innate immune response; intracellular signaling cascade; lipid metabolism; mitochondrion organization and biogenesis; protein complex assembly; protein kinase cascade; response to endogenous stimulus; response to oxidative stress; RNA processing; RNA splicing; secretion; transcription from RNA polymerase II promoter |
| ZF5* |
Actin polymerization and/or depolymerization; cell cycle; cell proliferation; cellular lipid metabolism; endocytosis; enzyme linked receptor protein signaling pathway; endoplasmic reticulum to Golgi vesicle-mediated transport; glycoprotein biosynthesis; hexose metabolism; induction of programmed cell death [47]; intracellular signaling cascade; JNK cascade; MAPKKK cascade; neurogenesis; phospholipid biosynthesis; protein amino acid glycosylation; protein kinase cascade; RNA splicing, via transesterification reactions; small GTPase mediated signal transduction; stress-activated protein kinase signaling pathway; ubiquitin cycle; vesicle-mediated transport; transcription from RNA polymerase II promoter [48] |
| ZIC3* |
Cell adhesion; cell cycle; apoptosis; cell proliferation; cell-cell signaling; chromatin modification; cytoskeleton organization and biogenesis; development [56]; endocytosis; enzyme linked receptor protein signaling pathway; hexose metabolism; MAPKKK cascade; nervous system development; neurogenesis [55]; protein kinase cascade; small GTPase mediated signal transduction; striated muscle development; transmembrane receptor protein tyrosine kinase signaling pathway; vesicle-mediated transport |
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*TFs have corresponding functions proven by experiments from previous studies. N/A stands for no enriched or conserved biological function categories from this study. | |
Hu et al. Genome Biology 2007 8:R257 doi:10.1186/gb-2007-8-12-r257 |
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