Table 3 |
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|
Function annotation for 51 homotypic TF combinations |
|
| TFs |
GO biological process categories |
|
|
|
| AP3 |
Cell adhesion; cellular localization; cellular process; extracellular matrix organization
and biogenesis; innate immune response; intracellular transport; second-messenger-mediated
signaling |
| CAAT* |
Cell cycle; cell division [36]; cell organization and biogenesis; chromosome organization
and biogenesis; DNA-dependent DNA replication; nucleobase, nucleoside, nucleotide
and nucleic acid metabolism; protein localization; steroid biosynthesis |
| CACBINDING PROTEIN |
Calcium ion transport; cellular process; intracellular signaling cascade; morphogenesis;
nervous system development; organ development; regulation of signal transduction |
| CEBPB |
Cellular carbohydrate metabolism |
| CETSP154 |
Cell organization and biogenesis; cellular localization; cellular process; organelle
organization and biogenesis; protein localization; ribosome biogenesis; ubiquitin
cycle; vesicle-mediated transport |
| CETS168 |
Cellular physiological process |
| CP2 |
N/A |
| CREB |
N/A |
| DBP |
Apoptosis; cell adhesion; endocytosis; innate immune response; intracellular signaling
cascade; lipid metabolism; phosphate transport; protein kinase cascade; response to
endogenous stimulus; RNA processing |
| DEAF1 |
N/A |
| DELTAEF1 |
Cell adhesion |
| E12 |
N/A |
| E2F1* |
Cell cycle [25-28]; cholesterol metabolism; nucleobase, nucleoside, nucleotide and
nucleic acid metabolism; sterol metabolism |
| EGR* |
Apoptosis; brain development; cell cycle; cell proliferation; central nervous system
development; development [49]; endocytosis; enzyme linked receptor protein signaling
pathway; galactose metabolism; intracellular signaling cascade; metal ion transport;
nervous system development [49]; protein amino acid phosphorylation; protein kinase
cascade; small GTPase mediated signal transduction; synaptic transmission; transcription
[37]; ubiquitin cycle |
| ETF* |
Cell cycle; cell proliferation; cellular lipid metabolism; central nervous system
development; dephosphorylation; endocytosis; enzyme linked receptor protein signaling
pathway; gluconeogenesis; heart development; hexose biosynthesis; intracellular signaling
cascade; muscle development; neurite morphogenesis [38]; programmed cell death; protein
kinase cascade; regulation of nucleocytoplasmic transport; response to DNA damage
stimulus; small GTPase mediated signal transduction |
| FAC1 |
Cell adhesion; cell cycle; cellular lipid metabolism; endocytosis; I-kappaB kinase/NF-kappaB
cascade; intracellular signaling cascade, via spliceosome; proteolysis; secretion.
carbohydrate metabolism; DNA repair; nuclear import; protein kinase cascade; protein
localization; response to endogenous stimulus; RNA splicing; ubiquitin cycle; vesicle-mediated
transport; cytoplasm organization and biogenesis; innate immune response; endoplasmic
reticulum to Golgi vesicle-mediated transport; microtubule cytoskeleton organization
and biogenesis; wound healing; protein amino acid glycosylation |
| FOX |
N/A |
| FREAC7 |
N/A |
| GATA1 |
N/A |
| GC* |
Apoptosis [35]; cell proliferation [35]; actin cytoskeleton organization and biogenesis;
cell cycle; cellular lipid metabolism; central nervous system development; endocytosis;
enzyme linked receptor protein signaling pathway; endoplasmic reticulum to Golgi vesicle-mediated
transport; gluconeogenesis; hexose biosynthesis; muscle development; nervous system
development; Notch signaling pathway; nucleocytoplasmic transport; protein kinase
cascade; small GTPase mediated signal transduction; synaptic transmission; transmembrane
receptor protein tyrosine kinase signaling pathway; ubiquitin cycle; vesicle-mediated
transport |
| HELIOSA |
Cellular physiological process; development; homophilic cell adhesion; regulation
of metabolism |
| HNF1* |
Organic anion transport [39]; innate immune response |
| HNF3B |
Lipid metabolism; DNA metabolism |
| IRF7* |
Immune response [40] |
| KROX* |
Actin cytoskeleton organization and biogenesis; cell cycle; enzyme linked receptor
protein signaling pathway; intracellular signaling cascade; nervous system development
[50]; phosphate metabolism; regulation of neurotransmitter levels; small GTPase mediated
signal transduction; system development; ubiquitin cycle |
| LBP1* |
Apoptosis [51]; cellular process; intracellular signaling cascade; protein amino acid
phosphorylation; protein kinase cascade |
| LDSPOLYA |
Development; aromatic amino acid family metabolism; intracellular signaling cascade |
| LEF1TDF1 |
N/A |
| LFA1 |
N/A |
| MAZ* |
Apoptosis; brain development; cell adhesion; cell cycle; cell differentiation; endocytosis;
enzyme linked receptor protein signaling pathway; intracellular signaling cascade;
muscle development [41]; nervous system development; development [41]; protein amino
acid phosphorylation; protein kinase cascade; regulation of actin filament length;
small GTPase mediated signal transduction; Wnt receptor signaling |
| MINI19 |
N/A |
| MMEF2 |
N/A |
| MYCMAX |
Cellular metabolism; macromolecule metabolism |
| MZF1* |
Cell proliferation [52]; cell adhesion; cell cycle; cell differentiation; cell-cell
signaling; enzyme linked receptor protein signaling pathway; hemopoiesis [52]; metal
ion transport; nervous system development; neurotransmitter secretion; organ development;
regulated secretory pathway; regulation of transcription, DNA-dependent; skeletal
development; synaptic transmission; Wnt receptor signaling pathway |
| NFAT* |
Immune response [29-31]; homophilic cell adhesion; organ development |
| NMYC |
Cellular physiological process |
| NRF2* |
Organelle organization and biogenesis [42]; cellular physiological process; protein
transport |
| OCT1 |
Apoptosis; cell-cell adhesion; cellular physiological process; protein transport |
| OSF2 |
N/A |
| PAX4 |
Cell proliferation; enzyme linked receptor protein signaling pathway; gamma-aminobutyric
acid signaling pathway; inflammatory response; programmed cell death; regulation of
kinase activity |
| PIT1 |
Proteolysis |
| PU1 |
Cell adhesion; regulation of kinase activity; regulation of transferase activity |
| S8* |
Development [46] |
| SP1* |
Cell differentiation [53]; cell proliferation [53]; apoptosis [35]; cell adhesion;
cell cycle; cell-cell signaling; cellular lipid metabolism; central nervous system
development; endocytosis; nervous system development; neurogenesis; nucleocytoplasmic
transport; organelle organization and biogenesis; phosphate metabolism; protein kinase
cascade; response to endogenous stimulus; Rho protein signal transduction; small GTPase
mediated signal transduction; synaptic transmission; transcription from RNA polymerase
II promoter; transmembrane receptor protein tyrosine kinase signaling pathway; ubiquitin
cycle; vesicle-mediated transport |
| SRF |
N/A |
| SRY |
Cell adhesion; cellular process; intracellular signaling cascade; mRNA processing;
organic acid metabolism; response to DNA damage stimulus; RNA metabolism; RNA splicing;
steroid metabolism |
| TBP |
Protein transport; establishment of protein localization; RNA processing |
| TFIII* |
Cell adhesion; cell differentiation; cell organization and biogenesis; chromatin modification;
enzyme linked receptor protein signaling pathway; intracellular signaling cascade;
nervous system development; organ development; protein kinase cascade; protein modification;
transcription, DNA-dependent [54] |
| XVENT1 |
Cell cycle; cell growth; cell proliferation; cellular biosynthesis; establishment
of cellular localization; inflammatory response; innate immune response; intracellular
signaling cascade; lipid metabolism; mitochondrion organization and biogenesis; protein
complex assembly; protein kinase cascade; response to endogenous stimulus; response
to oxidative stress; RNA processing; RNA splicing; secretion; transcription from RNA
polymerase II promoter |
| ZF5* |
Actin polymerization and/or depolymerization; cell cycle; cell proliferation; cellular
lipid metabolism; endocytosis; enzyme linked receptor protein signaling pathway; endoplasmic
reticulum to Golgi vesicle-mediated transport; glycoprotein biosynthesis; hexose metabolism;
induction of programmed cell death [47]; intracellular signaling cascade; JNK cascade;
MAPKKK cascade; neurogenesis; phospholipid biosynthesis; protein amino acid glycosylation;
protein kinase cascade; RNA splicing, via transesterification reactions; small GTPase
mediated signal transduction; stress-activated protein kinase signaling pathway; ubiquitin
cycle; vesicle-mediated transport; transcription from RNA polymerase II promoter [48] |
| ZIC3* |
Cell adhesion; cell cycle; apoptosis; cell proliferation; cell-cell signaling; chromatin
modification; cytoskeleton organization and biogenesis; development [56]; endocytosis;
enzyme linked receptor protein signaling pathway; hexose metabolism; MAPKKK cascade;
nervous system development; neurogenesis [55]; protein kinase cascade; small GTPase
mediated signal transduction; striated muscle development; transmembrane receptor
protein tyrosine kinase signaling pathway; vesicle-mediated transport |
|
|
|
|
*TFs have corresponding functions proven by experiments from previous studies. N/A stands for no enriched or conserved biological function categories from this study. |
|
|
Hu et al. Genome Biology 2007 8:R257 doi:10.1186/gb-2007-8-12-r257 |
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