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Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes

Kriston L McGary, Insuk Lee and Edward M Marcotte*

Genome Biology 2007, 8:R258 doi:10.1186/gb-2007-8-12-r258

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Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network

Bolan Linghu, Evan S Snitkin, Zhenjun Hu, Yu Xia, Charles DeLisi Genome Biology 2009, 10:R91 (3 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | Editor’s summary

An evidence-weighted functional-linkage network of human genes reveals associations among diseases that share no known disease genes and have dissimilar phenotypes

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Buffering by gene duplicates: an analysis of molecular correlates and evolutionary conservation

Kevin Hannay, Edward M Marcotte, Christine Vogel BMC Genomics 2008, 9:609 (16 December 2008)

Abstract | Full text | PDF | PubMed | Editor’s summary

Gene duplication does contribute to the robustness of organisms against disruption of gene function but it appears to have a smaller effect than might be expected across a range of organisms, particularly in some eukaryotes.

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