Figure 10.

Yeast genes with human orthologs linked to the same diseases are predicted better than random expectation. Predictability is measured as the area under a receiver operating characteristic (ROC) curve (AUC), as in Figure 3, measuring the AUC for each of 28 human diseases reported in the Online Mendelian Inheritance in Man (OMIM) disease database [51] that have four or more yeast orthologs annotated in the yeast function network and plotting the resulting AUC distributions. Real disease gene sets are significantly more predictable than size-matched random gene sets drawn from the set of yeast-human orthologs. Box plots are drawn as in Figure 3.