Table 1

Predictability of 100 yeast gene deletion phenotypes
Phenotypea
 AUC
 Seed genes with phenotype (n)
 Seed genes in network (n)
 Ref.
Caspofungin sensitive
 0.996
 20
 18
 [36]
Increased resistance to calcofluor white
 0.982
 10
 10
 [33]
Unipolar budding
 0.941
 10
 10
 [68]
CPY secretion (3)
 0.937
 46
 44
 [34]
Cell cycle arrest defective
 0.930
 8
 8
 [74]
UVC sensitive (high)
 0.919
 15
 14
 [75]
Sensitivity at 15 generations in galactose
 0.908
 17
 14
 [4]
CANR mutator (high)
 0.904
 18
 18
 [76]
Haploinsufficient in rich medium (YPD)
 0.898
 184
 184
 [77]
Cellular chitin level increased (3)
 0.873
 22
 21
 [33]
Bleomycin resistant (3)
 0.871
 5
 4
 [37]
Morphology: branched (diploid)
 0.870
 5
 5
 [4]
Sensitivity at 15 generations in 1.5 M sorbitol
 0.867
 6
 4
 [4]
Caspofungin resistant
 0.866
 8
 8
 [36]
Inviable (essential)
 0.845
 1100
 1027
 [4,30]
Shortened telomeres (3)
 0.843
 20
 18
 [32]
Sensitivity at 15 generations in minimal +his +leu +ura medium
 0.843
 77
 70
 [4]
MMS sensitive (3)
 0.837
 78
 73
 [78]
Cellular chitin level reduced (2)
 0.835
 17
 17
 [33]
Petite
 0.833
 179
 166
 [79]
Sensitivity at 5 generations in minimal +his +leu +ura medium
 0.827
 62
 51
 [4]
Long telomeres (3)
 0.824
 6
 6
 [32]
Decreased calcofluor white resistance
 0.814
 65
 63
 [77,80]
Growth defect on a fermentable carbon source
 0.812
 257
 249
 [81]
Transposon cDNA expression changed (high)
 0.810
 27
 26
 [82]
Morphology: clumpy (3)(diploid)
 0.802
 18
 18
 [4]
Gamma radiation sensitive (3)
 0.793
 31
 31
 [83]
Cell cycle arrest defective and defective shmoo
 0.782
 30
 29
 [74]
Sensitivity at 5 generations in galactose
 0.781
 11
 10
 [4]
Small (haploid)
 0.778
 215
 192
 [84]
Retrotransposition reduced
 0.772
 99
 89
 [82]
K1 killer toxin sensitive (40%)
 0.770
 72
 72
 [80]
Increased iron uptake
 0.757
 76
 70
 [35]
Growth defect on a non-fermentable carbon source
 0.755
 498
 448
 [81]
Gentamycin sensitive (high)
 0.754
 11
 11
 [85]
Proteasome inhibitor sens (high)
 0.753
 22
 22
 [86]
Reduced fitness in rich medium (YPD)
 0.748
 891
 872
 [77]
Mycophenolic acid sensitive
 0.746
 38
 33
 [87]
Axial budding
 0.745
 4
 4
 [68]
Morphology: elongate (3) (diploid)
 0.739
 77
 73
 [4]
Sporulation deficient
 0.738
 261
 244
 [88]
Random budding (high)
 0.737
 74
 72
 [68]
Large (haploid)
 0.728
 227
 205
 [84]
Reduced sporulation (3) (normal respiration)
 0.722
 136
 119
 [89]
Bleomycin sensitive (4)
 0.721
 58
 55
 [37]
Sensitivity at 5 generations in synthetic complete - lys medium
 0.715
 23
 22
 [4]
Decreased rapamycin resistance
 0.707
 272
 256
 [90]
Whi
 0.706
 19
 19
 [79]
Sensitivity at 5 generations in 1.5 M sorbitol
 0.704
 13
 11
 [4]
Decreased wortmannin resistance
 0.703
 89
 85
 [90]
Sensitivity at 20 generations in 1 M NaCl
 0.703
 63
 59
 [4]
K1 killer toxin resistant (40%)
 0.698
 19
 18
 [80]
Morphology: round (3) (diploid)
 0.696
 105
 99
 [4]
Uge
 0.694
 28
 26
 [79]
Sensitivity at 5 generations in synthetic complete - trp medium
 0.694
 48
 45
 [4]
Sensitivity at 5 generations in 1 M NaCl
 0.693
 60
 56
 [4]
Rapamycin resist (2)
 0.692
 26
 26
 [91]
Reduced iron uptake
 0.688
 5
 5
 [35]
Rate of growth loss of growth in 0.85 M NaCl
 0.682
 212
 189
 [92]
Sensitivity at 5 generations in medium of pH 8
 0.677
 102
 93
 [4]
Sensitivity at 15 generations in medium of pH 8
 0.676
 128
 115
 [4]
Morphology: small (3)(diploid)
 0.672
 79
 69
 [4]
Sensitivity at 15 generations in 10 uM nystatin
 0.672
 28
 27
 [4]
Morphology: large (3)(diploid)
 0.669
 88
 80
 [4]
Reduced glycogen storage (2)
 0.666
 44
 41
 [93]
Sensitivity at 5 generations in 10 uM nystatin
 0.666
 124
 108
 [4]
Increased rapamycin resistance
 0.662
 114
 100
 [90]
Morphology: unusual shmoo (haploid)
 0.661
 29
 25
 [74]
Morphology: polarized bud growth (haploid)
 0.657
 5
 5
 [74]
Wortmannin resistant (5)
 0.656
 25
 23
 [94]
Sensitivity at 5 generations in synthetic complete - thr medium
 0.647
 31
 29
 [5]
Enhanced glycogen storage (2)
 0.645
 61
 55
 [93]
Proteasome inhibitor resistant
 0.642
 7
 6
 [86]
Reduced spores per ascus
 0.641
 37
 34
 [89]
Rate of growth sensitivity in 0.85 M NaCl
 0.629
 209
 191
 [92]
Morphology: football (3) (diploid)
 0.628
 59
 53
 [5]
Germination deficient
 0.627
 158
 147
 [88]
Sporulation promoting
 0.622
 102
 98
 [88]
6AU sensitive (3)
 0.618
 28
 26
 [95]
Increased wortmannin resistance
 0.617
 80
 75
 [90]
Morphology: elongated (haploid)
 0.603
 110
 101
 [74]
Rapamycin sensitive (4)
 0.597
 20
 20
 [91]
Efficiency of growth sensitivity in 0.85 M NaCl
 0.597
 65
 58
 [92]
Decreased rapamycin resistance
 0.597
 8
 7
 [90]
Slow growth in YPD (16× below WT)
 0.585
 23
 22
 [4]
MPA sensitive (3)
 0.563
 24
 22
 [95]
Morphology: round (haploid)
 0.552
 13
 11
 [74]
Efficiency of growth resistance in 0.85 M NaCl
 0.541
 44
 40
 [92]
Sensitivity at 5 generations in synthetic complete medium
 0.531
 88
 78
 [5]
Morphology: large (haploid)
 0.527
 23
 21
 [74]
Adaptation time loss of growth in 0.85 M NaCl
 0.526
 103
 91
 [92]
Adaptation time sensitivity in 0.85 M NaCl
 0.521
 284
 259
 [92]
Decreased sensitivity to the anticancer drug, cisplatin
 0.512
 22
 19
 [96]
Morphology: chain (diploid)
 0.485
 5
 5
 [5]
Morphology: small (haploid)
 0.480
 94
 89
 [74]
Rate of growth resistance in 0.85 M NaCl
 0.479
 59
 49
 [92]
Morphology: clumped (haploid)
 0.479
 32
 28
 [74]
Adaptation time resistance in 0.85 M NaCl
 0.465
 69
 60
 [92]
Efficiency of growth loss of growth in 0.85 M NaCl
 0.464
 23
 21
 [92]
Morphology: pointed (haploid)
 0.453
 99
 88
 [74]

aNumbers in parentheses indicate threshold applied to generate seed set; for instance, '(3)' indicates '+++' or '---', as appropriate.

McGary et al. Genome Biology 2007 8:R258   doi:10.1186/gb-2007-8-12-r258

Open Data