Research
Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution
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* Corresponding author: Elena Giulotto elena.giulotto@unipv.it
1 Dipartimento di Genetica e Microbiologia 'Adriano Buzzati-Traverso', Università degli Studi di Pavia, Via Ferrata, 27100 Pavia, Italy
2 Istituto di Genetica Molecolare, CNR, Via Abbiategrasso, 27100 Pavia, Italy
Genome Biology 2007, 8:R260 doi:10.1186/gb-2007-8-12-r260
Published: 7 December 2007Additional files
Additional data file 1:
The four mechanisms of ITS insertion previously described [17].
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Additional data file 2:
The 128 mouse loci for which the orthologous rat loci were either not found or grossly rearranged and the 120 rat loci not found or rearranged in the mouse genome database.
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Additional data file 3:
The 58 ITS loci conserved in the two rodent species.
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Additional data file 4:
Mouse-specific and rat-specific ITSs together with the mechanism of their insertion and the number of nucleotides in register with the inserted telomeric repeats.
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Additional data file 5:
The 75 loci conserved in the two primate species and the three human loci for which the orthologous chimpanzee loci were not found or were grossly rearranged.
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Additional data file 6:
(a) Human-specific ITS loci; (b) chimpanzee-specific ITS loci; (c) ITS loci inserted before the human-chimpanzee split for which the insertion mechanism was described previously; (d) ITS loci conserved in human and chimpanzee and inserted within repetitive elements.
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Additional data file 7:
This figure shows how the mechanism of ITS insertion at DNA double strand break sites was deduced.
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Additional data file 8:
The sequence of all the TERC-ITS loci found in the rodent genomes and a description of their organization.
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