Figure 4.

Association of transcript abundance and clinical parameters in patients with acute KD (cohort 2). (a) Genes and samples are organized using hierarchical clustering as in Figure 1. Sample clusters C and D are explained in the text. Numbered vertical bars at the right of the heat map indicate gene sets described in the text and in Additional data file 4. b) Correlation coefficients were calculated for the expression of each gene and each of the following clinical parameters: percentage segmented neutrophils, percentage unsegmented neutrophils (band), percentage total neutrophils, percentage lymphocytes, age at onset, illness day, erythrocyte sedimentation rate (ESR), and level of C-reative protein (CRP). A p value was calculated using permutation, and assigned a negative or positive value corresponding to the direction of the correlation. Results are portrayed as a moving average along the y-axis, with a window size of 15 clones, and were plotted for a given parameter if the p value was less than 0.01 (marked by dotted line) over 10 or more consecutive array elements.