Research
Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes
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* Corresponding author: John Tower jtower@usc.edu
1 Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-1340, USA
2 Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92717, USA
3 Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, MD 20817-6735, USA
4 Department of Pathology and Laboratory Medicine, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9034, USA
5 Department of Oncology, University of Cambridge, Cambridge CB2 2XZ, UK
Genome Biology 2007, 8:R262 doi:10.1186/gb-2007-8-12-r262
Published: 9 December 2007Additional files
Additional data file 1:
Statistical analysis of the effect of DOX induced MnSOD over-expression on lifespan, stress resistance, desiccation, metabolism, and aconitase levels and LacZ expression assay.
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Additional data file 2:
Additional results for the effect of DOX-induced MnSOD over-expression on lifespan, stress resistance, desiccation, metabolism, and aconitase levels and LacZ expression assay.
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Additional data file 3:
DOX regulated immune response genes.
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Additional data file 4:
Annotated differentially expressed genes resulting from MnSOD over-expression.
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Additional data file 5:
Statistical significance of overlapping gene sets.
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Additional data file 6:
Categorization of the gene expression differences between MnSOD over-expressing flies and controls sampled at the same 'physiological' age.
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Additional data file 7:
Additional longevity promoting genes conserved between C. elegans daf-2 mutants and MnSOD over-expressing Drosophila.
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Additional data file 8:
MnSOD-regulated xenobiotic detoxification genes.
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Additional data file 9:
DNA regulatory elements in the set of conserved longevity promoting genes.
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Additional data file 10:
Supporting results and additional explanatory text.
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Additional data file 11:
Proposed role for HR96 in the endocrine regulation of lifespan.
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